Role of Hyaluronic Acid in Bone Healing After Dental Extraction
NCT ID: NCT02330822
Last Updated: 2015-09-29
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
20 participants
INTERVENTIONAL
2014-12-31
2015-09-30
Brief Summary
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Participants should have symmetric teeth that need extraction in the lower jaw. Hyaluronic acid will be injected following extraction in one of the two sides with random allocation.
cone-beam computerized tomography (CBCT) images will be taken for each participant immediately post-extraction and at six months post-operatively.
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Detailed Description
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Buccolingual distance and distomesial distance will be measured for each participant at 2 assessment times: directly post-extraction and six months post-extraction.
II- Radiographic examination variables:
Linear measurements Vertical bone fill Bone mineral density
Conditions
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Study Design
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RANDOMIZED
SINGLE_GROUP
TREATMENT
SINGLE
Study Groups
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Hyaluronic Acid Group
In this Group, Hyaluronic acid will be injected following extraction.
Hyaluronic Acid
This material is going to be injected into the extraction socket in order to promote bone healing.
Traditional Extraction Group
In this group, traditional extraction procedures will be followed.
No interventions assigned to this group
Interventions
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Hyaluronic Acid
This material is going to be injected into the extraction socket in order to promote bone healing.
Eligibility Criteria
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Inclusion Criteria
* Symmetric teeth requiring extraction in the lower jaw
* Systematically healthy
Exclusion Criteria
* Pregnancy (for female participants)
* Diabetic patients
* Patients with metabolic problems
18 Years
60 Years
ALL
Yes
Sponsors
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Damascus University
OTHER
Responsible Party
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Principal Investigators
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Sireen Abu Atta, DDS MSc
Role: PRINCIPAL_INVESTIGATOR
PhD student, Department of Oral and Maxillofacial Surgery, University of Damascus Dental School
Mazen Zenati, DDS MSc PhD
Role: STUDY_DIRECTOR
Professor of Oral and Maxillofacial Surgery, University of Damsacus Dental School
Locations
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Department of Oral and Maxillofacial Surgery, University of Damascus Dental School
Damascus, Damscus, Syria
Countries
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References
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Baldini A, Zaffe D, Nicolini G. Bone-defects healing by high-molecular hyaluronic acid: preliminary results. Ann Stomatol (Roma). 2010 Jan;1(1):2-7. Epub 2010 Jun 29.
Cardaropoli G, Araujo M, Hayacibara R, Sukekava F, Lindhe J. Healing of extraction sockets and surgically produced - augmented and non-augmented - defects in the alveolar ridge. An experimental study in the dog. J Clin Periodontol. 2005 May;32(5):435-40. doi: 10.1111/j.1600-051X.2005.00692.x.
de Brito Bezerra B, Mendes Brazao MA, de Campos ML, Casati MZ, Sallum EA, Sallum AW. Association of hyaluronic acid with a collagen scaffold may improve bone healing in critical-size bone defects. Clin Oral Implants Res. 2012 Aug;23(8):938-42. doi: 10.1111/j.1600-0501.2011.02234.x. Epub 2011 Jun 21.
Other Identifiers
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UDDS-OMFS-01-2015
Identifier Type: -
Identifier Source: org_study_id
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