Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
140 participants
OBSERVATIONAL
2014-12-31
2018-03-31
Brief Summary
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The investigators plan to examine the occurrence of HPV in testicular tissue from 100 azoospermic men and to compare with the HPV occurrence in testicular tissue from a control group of 40 normal, healthy men undergoing vasectomy. Since HPV, in a recent Danish study, was detected on sperm in 16% of 188 randomly selected semen donors, the investigators also plan to examine the occurrence of HPV on sperm ejaculated during the last week before vasectomy. If HPV should be found in testicular tissue from men belonging to the control group, it will be highly relevant to compare with the HPV occurrence on sperm ejaculated from the men in concern.
A Linear Array HPV Genotyping Kit from Roche will be used for detection of HPV in testicular tissue and ejaculates. In total, with this test kit 37 HPV genotypes are examined for, including 13 high risk types.
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Detailed Description
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Conditions
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Study Design
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CASE_CONTROL
PROSPECTIVE
Study Groups
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Azoospermic men
Testicular biopsy
Men with proven fertility
Testicular biopsy
Interventions
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Testicular biopsy
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* Men who do not understand the purpose and possible consequences of the study (both groups)
18 Years
MALE
Yes
Sponsors
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Odense University Hospital
OTHER
Responsible Party
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Jens Fedder
Professor, Consultant, Ph.D.
Locations
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Fertility Clinic, Odense University Hospital
Odense, , Denmark
Countries
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Other Identifiers
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Lab.Reprod.Biol.- Odense.02
Identifier Type: -
Identifier Source: org_study_id
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