Emergence Times and Airway Reactions in General Laryngeal Mask Airway Anesthesia

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

352 participants

Study Classification

INTERVENTIONAL

Study Start Date

2015-02-28

Study Completion Date

2016-02-29

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The aim of this study is first to assess if desflurane is superior in order to achieve a faster emergence from anesthesia.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

The Effect of Desflurane vs Sevoflurane on Perioperative Respiratory Complications in Laryngeal Mask Airway Anesthesia

NCT03006250

Anesthesia; Adverse Effect Laryngeal Masks Respiratory System Abnormalities

UNKNOWN PHASE4

Airway Responses During Desflurane Anesthesia Via a Laryngeal Mask Airway: Effects of Fentanyl Pretreatment

NCT01277861

Administration Site Reaction

COMPLETED PHASE4

Optimal End-Tidal (ET) Sevoflurane and Desflurane Concentration for Extubation of Supreme Laryngeal Mask Airway (LMA) in Adults

NCT01083953

Airway Complications

COMPLETED NA

Impact of Anesthetic Choice (Sevoflurane Versus Desflurane) on Airway Reflex Recovery in the Context of Antagonized Neuromuscular Block

NCT01199237

Airway Reflexes, Protective Recovery After Neuromuscular Block Anesthetic Recovery

COMPLETED PHASE4

Automated Control of Mechanical Ventilation During General Anaesthesia

NCT02644005

Anesthesia

COMPLETED

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

The aim of this study is first to assess if desflurane is superior in order to achieve a faster emergence from anesthesia (stating the date of birth) and second if desflurane is non-inferior in the occurrence of airway complications compared to sevoflurane or total intravenous anesthesia with propofol in the setting of laryngeal mask airway.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Anesthesia With Use of LMA (Laryngeal Mask Airway)

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Outcome Assessors

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

desflurane

Suprane® Dose: 0.8 MAC / 4-5 vol. % Mode of administration: inhalation with laryngeal mask One application

Group Type EXPERIMENTAL

Desflurane

Intervention Type DRUG

inhalation with laryngeal mask to maintain anaesthesia

sevoflurane

Sevoflurane:

Dose: 0.8 MAC / 1.2-1.4 vol.% Mode of administration: inhalation with laryngeal mask One application

Group Type ACTIVE_COMPARATOR

Sevoflurane

Intervention Type DRUG

inhalation with laryngeal mask to maintain anaesthesia

propofol

Propofol Dose: 5-7 mg kg-1 h-1 to maintain a BIS index value between 40 and 60 Mode of administration: intravenous One application

Group Type ACTIVE_COMPARATOR

propofol

Intervention Type DRUG

intravenous injection to maintain anaesthesia

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Desflurane

inhalation with laryngeal mask to maintain anaesthesia

Intervention Type DRUG

Sevoflurane

inhalation with laryngeal mask to maintain anaesthesia

Intervention Type DRUG

propofol

intravenous injection to maintain anaesthesia

Intervention Type DRUG

Other Intervention Names

Discover alternative or legacy names that may be used to describe the listed interventions across different sources.

Suprane Sevorane Anesia

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Planned anesthesia with use of LMA (laryngeal mask airway)
* Planned duration of anesthesia between 0.5 and 2 hours
* Age between 18-75 years
* Both gender
* Body mass index (BMI) \<35
* ASA 1-3
* Written informed consent prior to study participation

Exclusion Criteria

* Planned additional regional and local anesthesia
* Contra-indication for the use of a laryngeal mask airway
* Asthma
* COPD IV
* Known allergy or hypersensitivity to any drugs administered during this study
* Women who are pregnant, breast-feeding or women of childbearing potential not using adequate contraceptive methods
* Participation in a drug or device trial within the previous 30 days.
* Patients legally unable to give written informed consent.
* Patients with severe psychiatric disorders
* Recent (\<6 months) history of alcohol or drug abuse
* Patients with severe neuropsychiatric disorders
* Non-fluency in German language

Minimum Eligible Age

18 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No