Direct or Subacute Coronary Angiography in Out-of-hospital Cardiac Arrest
NCT ID: NCT02309151
Last Updated: 2024-06-18
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
1006 participants
INTERVENTIONAL
2014-12-31
2024-12-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
NONE
Study Groups
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Immediate coronary angiography
Immediate coronary angiography for out of hospital cardiac arrest patients with no signs of ST elevation on their first ECG after ROSC
Immediate coronary angiography
Immediate coronary angiography for out of hospital cardiac arrest patients with no signs of ST elevation on their first ECG after ROSC
Not immediate coronary angiography
Coronary angiography with possible coronary intervention may be performed at the discretion of the interventional cardiologist and should preferably not be performed until three days after the cardiac arrest. This strategy is in accordance with standard practice.
No interventions assigned to this group
Interventions
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Immediate coronary angiography
Immediate coronary angiography for out of hospital cardiac arrest patients with no signs of ST elevation on their first ECG after ROSC
Eligibility Criteria
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Inclusion Criteria
* Restoration of Spontaneous Circulation (ROSC) \>20 minutes
* Coronary angiography is expected to be performed within 120 minutes from inclusion and randomization at hospital
Exclusion Criteria
* Obvious extracardiac genesis of cardiac arrest such as trauma, hemorrhagic shock, and / or asphyxia (eg drowning, suffocation, hanging, exposure to fire smoke)
* Terminally ill patients with a life expectancy of less than 1 year
* Patients with ST-elevation
* Known pregnancy
* Patient awake GCS \>8 (Glasgow Coma Scale)
18 Years
ALL
No
Sponsors
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Uppsala University
OTHER
Responsible Party
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Principal Investigators
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Sten Rubertsson, Md,PhD
Role: PRINCIPAL_INVESTIGATOR
Uppsala Universtiy hospital
Locations
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Aalborg University hospital
Aalborg, , Denmark
Aarhus University Hospital
Aarhus, , Denmark
Odense University hospital
Odense, , Denmark
Amsterdam UMC
Amsterdam, , Netherlands
Albert Schweitzer Hospital
Dordrecht, , Netherlands
Catharina Ziekenhuis
Eindhoven, , Netherlands
Treant Hospital
Emmen, , Netherlands
Zuyderland Hospital
Heerlen, , Netherlands
Antonius Hospital
Nieuwegein, , Netherlands
Radboud University Medical Center
Nijmegen, , Netherlands
Haaglanden Medisch Centrum
The Hague, , Netherlands
Sahlgrenska Universitetssjukhuset
Gothenburg, , Sweden
Karolinska Universitetssjukhuset
Huddinge, , Sweden
Skånes Universitetssjukhus
Lund, , Sweden
Skåne Universitetssjukhus
Malmo, , Sweden
Örebro Universitetssjukhus
Örebro, , Sweden
Karolinska Universitetssjukhuset
Solna, , Sweden
Danderyd Sjukhus
Stockholm, , Sweden
Södersjukhuset AB
Stockholm, , Sweden
Umeå Universitetssjukhus
Umeå, , Sweden
Uppsala University hospital
Uppsala, , Sweden
Countries
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Central Contacts
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Facility Contacts
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Christian Juhl Terkelsen
Role: primary
Lisette Okkels Jensen
Role: primary
José Henriques
Role: primary
Rohit Oemrawsingh
Role: primary
Luuk Otterspoor
Role: primary
Rutger Anthonio
Role: primary
R van der Vleugel
Role: primary
Jan-Peter Van Kuijk
Role: primary
Judith Bonnes
Role: primary
Dirk Van Der Heijden
Role: primary
Peter Lundgren
Role: primary
Liyew Desta
Role: primary
Ludig Elfwen
Role: primary
Peter Gottfridsson
Role: primary
References
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Elfwen L, Lagedal R, Rubertsson S, James S, Oldgren J, Olsson J, Hollenberg J, Jensen U, Ringh M, Svensson L, Nordberg P. Post-resuscitation myocardial dysfunction in out-of-hospital cardiac arrest patients randomized to immediate coronary angiography versus standard of care. Int J Cardiol Heart Vasc. 2020 Mar 2;27:100483. doi: 10.1016/j.ijcha.2020.100483. eCollection 2020 Apr.
Elfwen L, Lagedal R, Nordberg P, James S, Oldgren J, Bohm F, Lundgren P, Rylander C, van der Linden J, Hollenberg J, Erlinge D, Cronberg T, Jensen U, Friberg H, Lilja G, Larsson IM, Wallin E, Rubertsson S, Svensson L. Direct or subacute coronary angiography in out-of-hospital cardiac arrest (DISCO)-An initial pilot-study of a randomized clinical trial. Resuscitation. 2019 Jun;139:253-261. doi: 10.1016/j.resuscitation.2019.04.027. Epub 2019 Apr 24.
Lagedal R, Elfwen L, James S, Oldgren J, Erlinge D, Ostlund O, Wallin E, Larsson IM, Lilja G, Cronberg T, Rubertsson S, Nordberg P. Design of DISCO-Direct or Subacute Coronary Angiography in Out-of-Hospital Cardiac Arrest study. Am Heart J. 2018 Mar;197:53-61. doi: 10.1016/j.ahj.2017.11.009. Epub 2017 Dec 5.
Other Identifiers
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DSC001
Identifier Type: -
Identifier Source: org_study_id
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