Postconditioning in the Treatment of Acute ST-segment Elevation Myocardial Infarction
NCT ID: NCT00507156
Last Updated: 2016-10-06
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
PHASE4
200 participants
INTERVENTIONAL
2007-07-31
Brief Summary
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The study investigates the effect on final infarct size evaluated by magnetic resonance scan of postconditioning of ST-segment elevation myocardial infarctions. Mechanical postconditioning is performed by means of several balloon inflations in the injured vessel following its acute re-opening.
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
SINGLE
Study Groups
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Mek postcon
Re-opening of the infarcted coronary artery by several balloon inflations separated by reperfusion of the vessel.
Mechanical postconditioning
Mechanical postconditioning with 4 cycles 30/30 sek balloon inflations
Standard treatment
Standard treatment (primary PCI)
Standard primary PCI
Acute re-opening of the occluded coronary artery
Interventions
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Standard primary PCI
Acute re-opening of the occluded coronary artery
Mechanical postconditioning
Mechanical postconditioning with 4 cycles 30/30 sek balloon inflations
Eligibility Criteria
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Inclusion Criteria
* STEMI \< 12 hours
* TIMI 0-1 in infarct related artery
Exclusion Criteria
* Cardiogenic shock
* Left main occlusions
* Lesions that cannot be treated with stents
* Previous CABG
* Pregnancy
* Severe renal insufficiency
* Previous extensive Q-wave infarction
* LBBB
18 Years
ALL
No
Sponsors
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Rigshospitalet, Denmark
OTHER
Responsible Party
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Thomas Engstrom
Chief Consultant
Principal Investigators
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Thomas Engstrom, D.Sci., PhD
Role: STUDY_CHAIR
Cheif Consultant
Locations
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Cardiac Catherization Lab., Heart Center, Rigshospitalet, University of Copenhagen
Copenhagen, , Denmark
Countries
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References
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Lonborg J, Holmvang L, Kelbaek H, Vejlstrup N, Jorgensen E, Helqvist S, Saunamaki K, Clemmensen P, Treiman M, Jensen JS, Engstrom T. ST-Segment resolution and clinical outcome with ischemic postconditioning and comparison to magnetic resonance. Am Heart J. 2010 Dec;160(6):1085-91. doi: 10.1016/j.ahj.2010.09.026.
Lonborg J, Kelbaek H, Vejlstrup N, Jorgensen E, Helqvist S, Saunamaki K, Clemmensen P, Holmvang L, Treiman M, Jensen JS, Engstrom T. Cardioprotective effects of ischemic postconditioning in patients treated with primary percutaneous coronary intervention, evaluated by magnetic resonance. Circ Cardiovasc Interv. 2010 Feb 1;3(1):34-41. doi: 10.1161/CIRCINTERVENTIONS.109.905521. Epub 2010 Jan 26.
Other Identifiers
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KF 01 326257
Identifier Type: -
Identifier Source: org_study_id
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