Post Cond No Reflow

NCT ID: NCT01208727

Last Updated: 2025-12-19

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

44 participants

Study Classification

INTERVENTIONAL

Study Start Date

2009-04-30

Study Completion Date

2011-03-31

Brief Summary

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After having shown that postconditioning allowed a significant 36% reduction of infarct size as assessed by blood levels of myocardial enzymes in acute myocardial patients, the investigators objective is to assess the effect of postconditioning in acute myocardial infarction (AMI) patients on microvascular obstruction lesions defined by cardiac MRI images.

Detailed Description

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Conditions

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Myocardial Reperfusion Injury

Keywords

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Myocardial infarction Postconditioning Microvascular obstruction No reflow MRI

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Control

22 controls patients without post conditionment

Group Type NO_INTERVENTION

No interventions assigned to this group

Intervention

22 posconditioned patients

Group Type EXPERIMENTAL

postconditioning

Intervention Type PROCEDURE

Direct postconditioning (brief repeated cycle of 4 occlusion and desocclusion of the initially occluded culprit coronary artery) after primary direct stenting.

Interventions

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postconditioning

Direct postconditioning (brief repeated cycle of 4 occlusion and desocclusion of the initially occluded culprit coronary artery) after primary direct stenting.

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Patients \> 18 years old,
* Male or female,
* Presenting first myocardial infarction, with the beginning of pains \< 12 hours,
* Requiring a revascularisation by primary angioplasty or " rescue " (after failure of thrombolysis) on IVA or RCA (not CA).
* Artery guilty with TIMI flow = 0

Exclusion Criteria

* cardiac arrest before the angioplasty,
* Cardiogenic shock
* Occlusion of the artery circumflex responsible for the infarction
* Magnetic resonance imaging: contre indication
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Hospices Civils de Lyon

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Pierre CROISILLE, MD

Role: STUDY_DIRECTOR

Hospices Civils de Lyon

Locations

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Hospices Civils de Lyon

Lyon, , France

Site Status

Countries

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France

References

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Thuny F, Lairez O, Roubille F, Mewton N, Rioufol G, Sportouch C, Sanchez I, Bergerot C, Thibault H, Cung TT, Finet G, Argaud L, Revel D, Derumeaux G, Bonnefoy-Cudraz E, Elbaz M, Piot C, Ovize M, Croisille P. Post-conditioning reduces infarct size and edema in patients with ST-segment elevation myocardial infarction. J Am Coll Cardiol. 2012 Jun 12;59(24):2175-81. doi: 10.1016/j.jacc.2012.03.026.

Reference Type RESULT
PMID: 22676937 (View on PubMed)

Other Identifiers

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2008-504

Identifier Type: -

Identifier Source: org_study_id