Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
12 participants
INTERVENTIONAL
2013-10-31
2014-02-28
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
CROSSOVER
TREATMENT
SINGLE
Study Groups
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A meal containing carrot and tributyrin
A meal containing 200 g grated carrot and 0.0216 mol tributyrin; blood test taken from 0 - 2 hours postprandial
Tributyrin
a triglyceride containing three C4-acids
Carrot
mainly water and glucose
A meal containing carrot and C8-diet oil
A meal containing 200 g grated carrot and 0.0216 mol of C8-diet oil; blood test taken from 0 - 2 hours postprandial
C8-diet oil
a triglyceride containing 2 C8-fatty acids and one oleic acid at sn-2 position
Carrot
mainly water and glucose
A meal containing carrot and olive oil
A meal containing 200 g grated carrot and 0.0216 mol of olive oil; blood test taken from 0 - 2 hours postprandial
Olive oil
a triglyceride containing mostly three oleic acids
Carrot
mainly water and glucose
A meal containing carrot
A meal containing 200 g grated carrot; blood test taken from 0 - 2 hours postprandial
Carrot
mainly water and glucose
Interventions
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Tributyrin
a triglyceride containing three C4-acids
C8-diet oil
a triglyceride containing 2 C8-fatty acids and one oleic acid at sn-2 position
Olive oil
a triglyceride containing mostly three oleic acids
Carrot
mainly water and glucose
Eligibility Criteria
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Inclusion Criteria
* Body mass index (BMI) 19 to 25 kg/m2
* Informed consent
Exclusion Criteria
* Diabetes mellitus
* Gastrointestinal diseases or operations interacting with intestinal absorption
18 Years
40 Years
MALE
Yes
Sponsors
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University of Copenhagen
OTHER
Glostrup University Hospital, Copenhagen
OTHER
Responsible Party
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Katrine Bagge Hansen
MD, PhD
Principal Investigators
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Jens J Holst, Professor
Role: STUDY_CHAIR
Biomedical Sciences, University of Copenhagen
Mette J Mandøe, Student
Role: PRINCIPAL_INVESTIGATOR
Glostrup Hospital; Biomedical Sciences, University of Copenhagen
References
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Mandoe MJ, Hansen KB, Hartmann B, Rehfeld JF, Holst JJ, Hansen HS. The 2-monoacylglycerol moiety of dietary fat appears to be responsible for the fat-induced release of GLP-1 in humans. Am J Clin Nutr. 2015 Sep;102(3):548-55. doi: 10.3945/ajcn.115.106799. Epub 2015 Jul 15.
Other Identifiers
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SFAS
Identifier Type: -
Identifier Source: org_study_id
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