Oxyntomodulin, Mechanisms of Action in Relation to Appetite, Food Intake, Gastric Emptying and Energy Expenditure.
NCT ID: NCT01232244
Last Updated: 2013-12-10
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
15 participants
OBSERVATIONAL
2010-10-31
2012-01-31
Brief Summary
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Therefore we want to investigate mechanistic relations between the three hormones.
Detailed Description
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Conditions
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Keywords
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Study Groups
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Healthy young males
GLP-1 infusion
1 pmol/kg/min
Glucagon infusion
3ng/kg/min
Oxyntomodulin infusion
3 pmol/kg/min
GLP-1 and glucagon infusion
1 pmol/kg/min 3 ng/kg/min
Placebo
NaCl 9 g/L infusion
Interventions
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GLP-1 infusion
1 pmol/kg/min
Glucagon infusion
3ng/kg/min
Oxyntomodulin infusion
3 pmol/kg/min
GLP-1 and glucagon infusion
1 pmol/kg/min 3 ng/kg/min
Placebo
NaCl 9 g/L infusion
Eligibility Criteria
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Inclusion Criteria
* Normal glucose tolerance
* Normal haemoglobin levels
* Informed content
Exclusion Criteria
* Pre diabetes (impaired glucose tolerance or impaired fasting glucose)
* 1st degree relatives with diabetes
* Obesity (BMI \> 30)
* Inflammatory bowels disease
* Bowels surgery
* Nephropathy
* Liver disease
* Medication which cannot be on hold for 24h
18 Years
70 Years
MALE
Yes
Sponsors
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University Hospital, Gentofte, Copenhagen
OTHER
Responsible Party
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Jonatan I Bagger
MD
Principal Investigators
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Jonatan I Bagger, MD
Role: PRINCIPAL_INVESTIGATOR
Gentofte University Hospital, University of Copenhagen
Locations
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Gentofte University Hospital
Hellerup, , Denmark
Countries
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References
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Bagger JI, Holst JJ, Hartmann B, Andersen B, Knop FK, Vilsboll T. Effect of Oxyntomodulin, Glucagon, GLP-1, and Combined Glucagon +GLP-1 Infusion on Food Intake, Appetite, and Resting Energy Expenditure. J Clin Endocrinol Metab. 2015 Dec;100(12):4541-52. doi: 10.1210/jc.2015-2335. Epub 2015 Oct 7.
Other Identifiers
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OXMDissek
Identifier Type: -
Identifier Source: org_study_id