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Diet Oil Induced Stimulation of GLP-1

NCT ID: NCT01453842

Last Updated: 2014-12-02

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

EARLY_PHASE1

Total Enrollment

12 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-03-31

Study Completion Date

2012-03-31

Brief Summary

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Activation of G protein-coupled receptor GPR119 stimulates glucagon-like peptide-1 (GLP-1)release from the intestinal L-cells. Previously, administration of 2-oleyl-glycerol (2-OG) to humans significantly increased plasma GLP-1. In the present study we want to test the effect in patients with type 2 diabetes. The hypothesis is that we will expect to find a significant increased plasma GLP-1 following a meal containing of 2-OG when compared to meals containing of olive oil or carbohydrates alone.

Detailed Description

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Activation of G protein-coupled receptor GPR119 stimulates glucagon-like peptide-1 (GLP-1)release from the intestinal L-cells. Previously, administration of 2-oleyl-glycerol (2-OG) to humans significantly increased plasma GLP-1. In the present study we want to test the effect in patients with type 2 diabetes. The hypothesis is that we will expect to find a significant increased plasma GLP-1 following a meal containing of 2-OG when compared to meals containing of olive oil or carbohydrates alone. The aim of the study is to elucidate the effect of 2-OG, 'diet oil' on GLP-1 secretion in patients with type 2 diabetes and to explain the mechanism behind the known stimulation of GLP-1 release by dietary fat.

Conditions

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Type 2 Diabetes Mellitus

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

SINGLE

Participants

Study Groups

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Diet oil

Group Type EXPERIMENTAL

Diet oil

Intervention Type DIETARY_SUPPLEMENT

Carrot and diet oil (containing 2-OG) and 1½ g of paracetamol

Olive oil

Group Type ACTIVE_COMPARATOR

Olive oil

Intervention Type DIETARY_SUPPLEMENT

Carrot and olive oil and 1½ g of paracetamol

Carrot

Group Type PLACEBO_COMPARATOR

Carrot

Intervention Type DIETARY_SUPPLEMENT

Carrot and 1½ g of paracetamol

Interventions

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Diet oil

Carrot and diet oil (containing 2-OG) and 1½ g of paracetamol

Intervention Type DIETARY_SUPPLEMENT

Olive oil

Carrot and olive oil and 1½ g of paracetamol

Intervention Type DIETARY_SUPPLEMENT

Carrot

Carrot and 1½ g of paracetamol

Intervention Type DIETARY_SUPPLEMENT

Eligibility Criteria

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Inclusion Criteria

* Patients with type 2 diabetes mellitus according to the WHO criteria
* caucasians
* age above 18 years
* BMI 20-30

Exclusion Criteria

* kidney disease
* liver disease
* retinopathy
* anaemia
* use of insulin
* use of GLP-1 analogues
* use of DPP-4 inhibitors
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University of Copenhagen

OTHER

Sponsor Role lead

Responsible Party

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Katrine Bagge Hansen

MD

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Katrine B Hansen, MD

Role: STUDY_CHAIR

University of openhagen

Jens J Holst, Professor

Role: STUDY_CHAIR

University of Copenhagen

Harald S Hansen, Professor

Role: STUDY_CHAIR

University of Copenhagen

Locations

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Department of Clinical Physiology

Glostrup Municipality, , Denmark

Site Status

Countries

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Denmark

Other Identifiers

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Diet oil

Identifier Type: -

Identifier Source: org_study_id