Bile Acid-induced GLP-secretion. A Study in Cholecystectomized Subjects
NCT ID: NCT01251510
Last Updated: 2013-01-23
Study Results
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Basic Information
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COMPLETED
20 participants
OBSERVATIONAL
2010-10-31
2011-06-30
Brief Summary
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The goal of the present project is to unravel the importance of bile acid-induced GLP-1 secretion (via the G protein-coupled receptor TGR5) in human physiology.
In the present study the investigators examine the GLP-1 secretion in healthy subjects and cholecystectomised patients. Thereby the investigators aim to show, that cholecystectomised patients have reduced bileflow after a meal, and as a consequence exhibit a diminished GLP-1 response as compared to healthy subjects.
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Detailed Description
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Conditions
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Study Groups
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Healthy adults
No interventions assigned to this group
Type 2 diabetes
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* Normal glucose tolerance
* Normal haemoglobin levels
* Informed content
* Laparoscopic cholecystectomy \<6 months. Indication: Gallstones.
* Normal fasting plasma glucose
* Normal glucose tolerance
* Normal haemoglobin levels
* Informed content
Exclusion Criteria
* Pre diabetes (impaired glucose tolerance or impaired fasting glucose)
* 1st degree relatives with diabetes
* Obesity (BMI \> 30)
* Inflammatory bowels disease
* Nephropathy
* Liver disease
* Medication which cannot be on hold for 24h
18 Years
70 Years
ALL
Yes
Sponsors
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University Hospital, Gentofte, Copenhagen
OTHER
Responsible Party
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David P. Sonne
MD
Principal Investigators
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David P. Sonne, MD
Role: PRINCIPAL_INVESTIGATOR
Gentofte Hospital, University of Copenhagen
Locations
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Gentofte University Hospital
Hellerup, , Denmark
Countries
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References
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Sonne DP, Hare KJ, Martens P, Rehfeld JF, Holst JJ, Vilsboll T, Knop FK. Postprandial gut hormone responses and glucose metabolism in cholecystectomized patients. Am J Physiol Gastrointest Liver Physiol. 2013 Feb 15;304(4):G413-9. doi: 10.1152/ajpgi.00435.2012. Epub 2012 Dec 28.
Other Identifiers
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GAL-INK I
Identifier Type: -
Identifier Source: org_study_id
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