The Effects of GIP and GLP-2 on the Secretion of Glucagon in Patients With Type 1 Diabetes

NCT ID: NCT00732602

Last Updated: 2009-02-13

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

8 participants

Study Classification

INTERVENTIONAL

Study Start Date

2008-01-31

Brief Summary

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The purpose of this study is to determine whether Glucose-dependent Insulinotropic Polypeptide (GIP) or Glucagon Like Peptide 2 (GLP-2) has an affect on the secretion of Glucagon from the pancreas in patients with type 1 diabetes mellitus.

Detailed Description

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Conditions

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Diabetes Mellitus

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

SINGLE

Participants

Study Groups

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B

GLP-2 infusion

Group Type ACTIVE_COMPARATOR

GLP-2 infusion

Intervention Type OTHER

C

Sodium-chloride infusion

Group Type PLACEBO_COMPARATOR

Sodium-chloride

Intervention Type OTHER

A

GIP-infusion

Group Type ACTIVE_COMPARATOR

GIP-infusion

Intervention Type OTHER

Interventions

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GIP-infusion

Intervention Type OTHER

Sodium-chloride

Intervention Type OTHER

GLP-2 infusion

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Caucasians over 18 years with type 1 diabetes (WHO criteria)
* Arginine test without rise in plasma C-peptide
* Normal blood Hemoglobin
* Informed consent

Exclusion Criteria

* Liver disease
* Diabetic nephropathy
* Treatment with medications unpausable for 12 hours
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University of Copenhagen

OTHER

Sponsor Role collaborator

University Hospital, Gentofte, Copenhagen

OTHER

Sponsor Role lead

Responsible Party

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University Hospital, Gentofte, Copenhagen

Locations

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University Hospital, Gentofte

Hellerup, Capital Region, Denmark

Site Status

Countries

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Denmark

Other Identifiers

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H-D-2007-0058

Identifier Type: -

Identifier Source: org_study_id

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