Serum CTRP3 and RBP4 Levels in Obesity and Hypertension

NCT ID: NCT02226471

Last Updated: 2014-08-27

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 2000 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2012-03-31
• Study Completion Date: 2014-02-28

Brief Summary

Insulin resistance is closely correlated with obesity and cardiovascular disease. Adipokines may play important roles in the pathogenesis of obesity, which are a link between obesity and obesity-related disorders.C1q/TNF-related protein-3 (CTRP3) and retinol-binding protein 4 (RBP4) are novel adipokine that modulates the action of insulin in various diseases. This study addressed the relationship between CTRP3, RBP4 and IR in newly diagnosed obesity and essential hypertension.

Detailed Description

Serum CTRP3 and RBP4, anthropometric and metabolic parameters were determined in 480 newly diagnosed obesity and essential hypertensive patients not taking anti-obese and antihypertensive medications and 66 normal weight (NW) and normotensive subjects. All subjects were divided into two groups depending on body mass index (BMI), including NW group and obesity group, and then four subgroups were divided according to obesity and hypertension, including NW-normal blood pressure subgroup (NW-NBP), NW-hypertension subgroup (NW-HTN), obese-normal blood pressure subgroup (OB-NBP), obese-hypertension subgroup (OB-HTN).

Conditions

Obesity; Hypertension

Study Design

• Observational Model Type: CASE_CROSSOVER
• Study Time Perspective: CROSS_SECTIONAL

Study Groups

NW-NBP group

normal weight and blood pressure subjects

No interventions assigned to this group

NW-HTN group

Normal weight with hypertension subjects

No interventions assigned to this group

OB-NBP group

obese-normal blood pressure subjects

No interventions assigned to this group

OB-HTN group

Obese-hypertension subjects

No interventions assigned to this group

Eligibility Criteria

Inclusion Criteria

1. Hypertension not taking antihypertensive medications

2. Obesity not taking anti-obese or lipid-lowering medications

Exclusion Criteria

1. Heart failure;

2. pregnant or lactating

3. diabetes

4. thyroid disease

5. fractures

6. osteoporosis

7. tumors;

• Minimum Eligible Age: 20 Years
• Maximum Eligible Age: 70 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Third Military Medical University

OTHER

Sponsor Role: lead

Responsible Party

Deng Wu Quan

Chongqing southwest hospital

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Deng Wuquan, PHD

Role: STUDY_DIRECTOR

Southwest Hospital, China

References

Deng W, Li C, Zhang Y, Zhao J, Yang M, Tian M, Li L, Zheng Y, Chen B, Yang G. Serum C1q/TNF-related protein-3 (CTRP3) levels are decreased in obesity and hypertension and are negatively correlated with parameters of insulin resistance. Diabetol Metab Syndr. 2015 Apr 10;7:33. doi: 10.1186/s13098-015-0029-0. eCollection 2015.

Reference Type: DERIVED

PMID: 25878729 (View on PubMed)

Related Links

http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0055744

Implication of Progranulin and C1q/TNF-Related Protein-3 (CTRP3) on Inflammation and Atherosclerosis in Subjects with or without Metabolic Syndrome

http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0099785

Identification of Adipokine Clusters Related to Parameters of Fat Mass, Insulin Sensitivity and Inflammation

Other Identifiers

SW1000

Identifier Type: -

Identifier Source: org_study_id