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Adiponectin, Leptin, h-CRP Values in Obese Children - Important Markers for Metabolic Syndrome?

NCT ID: NCT03354676

Last Updated: 2017-11-28

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

122 participants

Study Classification

OBSERVATIONAL

Study Start Date

2016-03-11

Study Completion Date

2017-09-10

Brief Summary

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Obesity is a chronic inflammatory disorder in which leptin, adiponectin and C reactive protein (CRP) play an important role. This study aimed to investigate the relationship between markers of adiposity like leptin, adiponectin and high sensitive C reactive protein (hsCRP) in obese children, and to determine whether these adipokines are significant markers in defining metabolic syndrome in pediatric population

Detailed Description

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The idea that adipose tissue is just a form of energy storage has changed dramatically in recent years. Currently, adipose tissue is considered to be a true endocrine gland that fulfills multiple roles in regulating different biological functions. Communication between adipose tissue and the rest of the systems is accomplished through bioactive mediators (adipokines) Adipokines control energy homeostasis and are involved in metabolic, endocrine and immunological processes.This study aimed to investigate the relationship between markers of adiposity like leptin, adiponectin and high sensitive C reactive protein (hsCRP) in obese children, and to determine whether these adipokines are significant markers in defining metabolic syndrome in pediatric population.The current retrospective observational study was conducted at the "Louis Turcanu" Emergency Hospital Timisoara over a period of one year, from July 2013 and June 2014. All inborn patient files were analyzed as anonymised limited data sets from archived records of the Endocrinology, Diabetology and Cardiology department.

Conditions

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Obesity, Metabolically Benign

Keywords

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adipokines, metabolic syndrome, obese children

Study Design

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Observational Model Type

COHORT

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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MetS+

Obese group with metabolic syndrome/Data processing from Patient Medical Files

MetS+

Intervention Type OTHER

Data processing from Patient Medical Files

MetS-

Obese group without metabolic syndrome/Data processing from Patient Medical Files

MetS-

Intervention Type OTHER

Data processing from Patient Medical Files

Interventions

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MetS+

Data processing from Patient Medical Files

Intervention Type OTHER

MetS-

Data processing from Patient Medical Files

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* obese children (BMI\> 95th percentile)

Exclusion Criteria

* obesity caused by endocrine disease, syndromic obesity, systemic disease or acute illness.
Minimum Eligible Age

4 Years

Maximum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University of Medicine and Pharmacy "Victor Babes" Timisoara

OTHER

Sponsor Role collaborator

Alexandru Florin Rogobete

OTHER

Sponsor Role lead

Responsible Party

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Alexandru Florin Rogobete

MSc, PhDs, Clinical Researcher

Responsibility Role SPONSOR_INVESTIGATOR

Principal Investigators

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Alexandru Florin Rogobete, PhDS

Role: PRINCIPAL_INVESTIGATOR

Romanian Society of Anesthesia and Intensive Care

References

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Beyazit F, Unsal MA. Obesity and insulin resistance are significant predictors of serum leptin levels. J Turk Ger Gynecol Assoc. 2017 Sep 1;18(3):158-159. doi: 10.4274/jtgga.2017.0027. No abstract available.

Reference Type BACKGROUND
PMID: 28890432 (View on PubMed)

Lopez-Quintero A, Garcia-Zapien AG, Flores-Martinez SE, Diaz-Burke Y, Gonzalez-Sandoval CE, Lopez-Roa RI, Medina-Diaz E, Munoz-Almaguer ML, Sanchez-Corona J. Contribution of polymorphisms in the LEP, LEPR and RETN genes on serum leptin and resistin levels in young adults from Mexico. Cell Mol Biol (Noisy-le-grand). 2017 Aug 30;63(8):10-18. doi: 10.14715/cmb/2017.63.8.3.

Reference Type BACKGROUND
PMID: 28886308 (View on PubMed)

Bagherniya M, Khayyatzadeh SS, Heidari Bakavoli AR, Ferns GA, Ebrahimi M, Safarian M, Nematy M, Ghayour-Mobarhan M. Serum high-sensitive C-reactive protein is associated with dietary intakes in diabetic patients with and without hypertension: a cross-sectional study. Ann Clin Biochem. 2018 Jul;55(4):422-429. doi: 10.1177/0004563217733286. Epub 2017 Nov 23.

Reference Type BACKGROUND
PMID: 28882065 (View on PubMed)

Other Identifiers

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12870

Identifier Type: -

Identifier Source: org_study_id