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Glypican4 and CTRP5 in Metabolic Syndrome and the Effect of Exercise on These Adipokines

NCT ID: NCT01688622

Last Updated: 2012-09-21

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

90 participants

Study Classification

INTERVENTIONAL

Study Start Date

2012-07-31

Study Completion Date

2012-09-30

Brief Summary

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Glypican4, CTRP3, CTRP5 are emerging novel adipokines mediating obesity and inflammation related disorders. RBP4 and adiponectin are well known important adipokines. Therefore, we examine the circulating levels of theses adipokines in the subjects with or without metabolic syndrome. Furthermore, we tried to clarify the effect of exercise on the circulating these adipokines.

Detailed Description

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Conditions

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Metabolic Syndrome Obesity

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Blinding Strategy

NONE

Study Groups

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Exercise

obese women who are volunteers for the 3 months exercise programs

Group Type OTHER

3months Exercise

Intervention Type BEHAVIORAL

training session consisting of a brief warm-up, followed by an approximately 45-min session of aerobic exercise at an intensity of 60-75% of the age-predicted maximum heart rate (approximately 300 kcal/day) and a 20-min muscle strength train- ing programme (approximately 100 kcal/day), followed by a brief cool-down period.

Interventions

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3months Exercise

training session consisting of a brief warm-up, followed by an approximately 45-min session of aerobic exercise at an intensity of 60-75% of the age-predicted maximum heart rate (approximately 300 kcal/day) and a 20-min muscle strength train- ing programme (approximately 100 kcal/day), followed by a brief cool-down period.

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* Women between 30 and 60 years of age who had a body mass index (BMI) more than 25 kg/m2
* The subjects of metabolic syndrome and age, gender matched non metabolic syndrome among the participants of Korean SO Study (KSOS) study, which is an ongoing epidemiologic study supported by the Korea Science and Engineering Foundation

Exclusion Criteria

* participants had a history of cardiovascular disease
* any type of diabetes
* stage 2 hypertension
* malignant disease, severe renal, or hepatic disease
* Subjects taking medications that might affect body weight or body composition
Minimum Eligible Age

20 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Korea University

OTHER

Sponsor Role lead

Responsible Party

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K. M. Choi

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Korea University Guro Hospital

Seoul, , South Korea

Site Status

Countries

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South Korea

References

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Choi HY, Park JW, Lee N, Hwang SY, Cho GJ, Hong HC, Yoo HJ, Hwang TG, Kim SM, Baik SH, Park KS, Youn BS, Choi KM. Effects of a combined aerobic and resistance exercise program on C1q/TNF-related protein-3 (CTRP-3) and CTRP-5 levels. Diabetes Care. 2013 Oct;36(10):3321-7. doi: 10.2337/dc13-0178. Epub 2013 Jun 18.

Reference Type DERIVED
PMID: 23780948 (View on PubMed)

Yoo HJ, Hwang SY, Cho GJ, Hong HC, Choi HY, Hwang TG, Kim SM, Bluher M, Youn BS, Baik SH, Choi KM. Association of glypican-4 with body fat distribution, insulin resistance, and nonalcoholic fatty liver disease. J Clin Endocrinol Metab. 2013 Jul;98(7):2897-901. doi: 10.1210/jc.2012-4297. Epub 2013 Apr 30.

Reference Type DERIVED
PMID: 23633195 (View on PubMed)

Other Identifiers

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KoreaSO_Exercise

Identifier Type: -

Identifier Source: org_study_id