Childhood Metabolic Markers of Adult Morbidity in Blacks
NCT ID: NCT01312051
Last Updated: 2017-10-18
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
156 participants
OBSERVATIONAL
2004-07-31
2011-09-20
Brief Summary
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The specific aims of this project are: 1) to compare skeletal muscle lipid content (SMLC) in black vs white children by computed tomography (CT) scan of the mid-thigh, and assess the relationship to in vivo insulin sensitivity; 2) to test the hypothesis that free fatty acid (FFA) - induced insulin resistance is associated with larger increases in intramyocellular lipid (IMCL) in black vs white adolescents; 3) to examine if β-cell insulin secretion in prepubertal black children is more sensitive to the stimulatory effect of FFA than in whites; and 4) to test if the β-cell in black obese adolescents is more susceptible to the lipotoxic effect of FFA compared with whites. The methods to be used are: the well- established CT method as well as Magnetic Resonance Spectroscopy (1H-MRS) to assess SMLC and IMCL; intralipid infusion to elevate circulating FFA levels; the hyperinsulinemic-euglycemic clamp with stable isotopes and indirect calorimetry to measure insulin sensitivity and substrate turnover; the hyperglycemic clamp to assess insulin secretion; DEXA and whole body MRI for body composition assessments.
Detailed Description
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Conditions
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Study Design
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OTHER
CROSS_SECTIONAL
Study Groups
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Protocol 1
Healthy, overweight 11 to 17 year old black and white adolescents
No interventions assigned to this group
Protocol 2
Healthy, normal-weight 11 to 17 year old black and white adolescents
No interventions assigned to this group
Protocol 3
Healthy, normal-weight 8 to 12 year old black and white adolescents
No interventions assigned to this group
Protocol 4
Healthy, overweight 11 to 17 year old black and white adolescents
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* Age 11-17 years
* Male or Female
* Healthy
* Obese, BMI ≥ 95 percentile
* Pubertal/Tanner Stage II-V
* African American or White American, based on self identity with no admixture for 3 generations
Protocol 2:
* Age 11-17 years
* Male or Female
* Healthy
* Normal Weight, BMI 10- 95 percentile
* Pubertal/Tanner Stage II-V
* African American or White American, based on self-identity with no admixture for 3 generations
Protocol 3:
* Age 8-12 years
* Male or Female
* Healthy
* Normal Weight, BMI 10-95 percentile
* Prepubertal/Tanner Stage I
* African American or White American, based on self-identity with no admixture for 3 generations
Exclusion Criteria
* Hemocue \< 12 gm/dl in pubertal subjects and \<11gm/dl in prepubertal subjects
* Positive serum pregnancy test
* Recent significant weight change or dieting
* Presence of disease (i.e.diabetes, hypothyroidism, genetic dyslipidemia, etc)
8 Years
17 Years
ALL
Yes
Sponsors
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National Institutes of Health (NIH)
NIH
University of Pittsburgh
OTHER
Responsible Party
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Silva Arslanian
Professor
Locations
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Children's Hospital of Pittsburgh of UPMC
Pittsburgh, Pennsylvania, United States
Countries
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Other Identifiers
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