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Study on Correlation Between Vascular ET-1 and Adiponectin in Pediatric Obesity

NCT ID: NCT01750333

Last Updated: 2012-12-17

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

60 participants

Study Classification

OBSERVATIONAL

Study Start Date

2012-04-30

Study Completion Date

2013-03-31

Brief Summary

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The aim of this study is to explore whether and how high circulating levels of endothelin-1 (ET-1) in obese and overweight children may contribute to impair adiponectin (Ad) production, release and vascular activity

Detailed Description

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Conditions

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OBESITY Endothelial Dysfunction Insulin Resistance

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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Lean children

No interventions assigned to this group

Overweight Children (OW)

No interventions assigned to this group

Obese children (Ob)

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Children will be enrolled into lean, overweight or obese groups based on Body mass index (BMI) calculated according to standard methods. International standards for sex-and age-specific BMI centiles for subjects aged 2-18 years will be used. The 95th centile of BMI reference is the cut off point for childhood obesity. Overweight and obese children are defined as those with a BMI higher than the centile curves.

Exclusion Criteria

* presence of renal, liver and/or cardiovascular diseases;
* hypertension;
* metabolic and/or endocrine disorders;
* genetic syndromes;
* histories of chronic allergies, acute infectious or inflammatory diseases during the last 3 months preceding the study
Minimum Eligible Age

5 Years

Maximum Eligible Age

13 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Monica Montagnani

INDIV

Sponsor Role lead

Responsible Party

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Monica Montagnani

Medical School Faculty Member - Professor of Pharmacology

Responsibility Role SPONSOR_INVESTIGATOR

Principal Investigators

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Monica Montagnani, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

University of Bari Medical School

Locations

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University of Bari Medical School - Dept Biomedical Sciences and Human Oncology

Bari, , Italy

Site Status

Countries

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Italy

Other Identifiers

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OBETAD-01

Identifier Type: -

Identifier Source: org_study_id