Liver Stiffness Measurement in Alcohol-dependent Subjects in Relation to Abstinence After Withdrawal
NCT ID: NCT02202148
Last Updated: 2017-01-31
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
195 participants
OBSERVATIONAL
2015-07-31
2016-12-31
Brief Summary
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Liver stiffness variation is one of the major somatic effect of chronic alcohol consumption. It is a consequence of numerous mechanisms, including inflammation. Liver stiffness seems to depend on alcohol consumption in alcohol dependent patient, more precisely on the time after the last alcohol consumption. This is very few documented after alcohol withdrawal, and has never been explored during several months after withdrawal as a function of alcohol consumption and abstinence.
Brain Derived neurotrophic Factor (BDNF) seems to play a major role in general homeostasis and also liver function.
We propose here to analyse the serum BDNF levels variations after withdrawal according to liver stiffness levels and alcohol consumption status.
We will also measure liver stiffness using Fibroscan® in alcohol dependent subjects included in the main study to search for a link with serum BDNF levels and abstinence at day 0, 14, 28 and months 2, 4, and 6.
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Detailed Description
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Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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alcohol withdrawal
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* criteria from the main study
Exclusion Criteria
18 Years
ALL
No
Sponsors
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Hôpital Dupuytren
OTHER
Centre Hospitalier Esquirol
OTHER
Responsible Party
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Philippe Nubukpo
MD, PhD
Principal Investigators
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Philippe Nubukpo, MD, PhD
Role: PRINCIPAL_INVESTIGATOR
Centre Hospitalier Esquirol
Locations
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Centre Hospitalier Esquirol
Limoges, , France
Countries
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Other Identifiers
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2014-A00854-43
Identifier Type: -
Identifier Source: org_study_id
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