Substrate Metabolism During Exercise Following Ingestion of Ethanol

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

8 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-11-13

Study Completion Date

2018-06-29

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

This study will investigate how ethanol (pure alcohol) influences carbohydrate and fat metabolism during prolonged, moderate intensity exercise. Participants will perform two bouts of cycling exercise with or without prior ingestion of ethanol, in a randomised order, separated by one week.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

The Effects of Ethanol on Intestinal Permeability and Gut Hormones

NCT03348371

Insulin Resistance Ethanol Incretin Effect

COMPLETED NA

Beer or Ethanol Effects on the Response to High Intensity Interval Training: A Controlled Study in Healthy Individuals

NCT03660579

Drinking, Alcohol Exercise

COMPLETED NA

Human Auto-ethanol Formation and Acetate Signaling

NCT05130619

Healthy

RECRUITING NA

Metabolic Imprints of Alcoholic Beverages

NCT03384147

Metabolic Side Effects of Drugs and Substances

COMPLETED NA

The Impact of Oral Ethanol and Vaped Ethanol on the Evaluation of Impairment

NCT04522973

Electronic Cigarette Use

COMPLETED NA

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Very little research has investigated the influence of ethanol on metabolism during prolonged exercise. Evidence suggests that delivery of fat to the working muscles during exercise may be limited with ethanol and therefore this may shift the relative proportions of energy derived from muscle stores of carbohydrate as a result (Jorfeldt \& Juhlin-Dannfelt, 1976).

The current study aims to investigate how a small-moderate dose of ethanol influences where energy is derived from during a prolonged bout of moderate intensity cycling exercise.

Participants will visit the lab on three occasions, once for preliminary measurements of fitness and body composition, and twice for the experimental bouts of exercise. Body composition will be assessed using a dual-energy x-ray absorptiometry (DEXA) scan, which will measure lean mass, fat mass, and bone mineral density. Participants will then perform an incremental maximal oxygen uptake test to determine intensity for the experimental bouts of exercise.

The two experimental bouts of exercise include cycling on an exercise bike for 2 hours at 55% of their maximal oxygen uptake (i.e. fitness) following 1 hours rest. This will be performed under two conditions: with and without ethanol ingestion. Pre and post exercise muscle biopsies will be collected to assess muscle metabolism, with regular blood samples and expired breath samples being collected to further investigate fuel delivery and use by the working tissues. The experimental bouts of exercise will be performed 1 week apart in a randomised order.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Exercise Metabolism Following Ethanol Ingestion

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Ethanol

Participants will ingest ethanol (in the form of 40% ethanol) at an ingestion rate of 0.1 grams/kg lean body mass/hour in a solution with water.

Group Type EXPERIMENTAL

Ethanol

Intervention Type DIETARY_SUPPLEMENT

For one exercise session, participants will be asked to ingest a quantity of ethanol (in the form of vodka) sufficient to maximally stimulate liver alcohol metabolism.

No Ethanol

Participants will ingest a volume matched beverage of water only.

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Ethanol

For one exercise session, participants will be asked to ingest a quantity of ethanol (in the form of vodka) sufficient to maximally stimulate liver alcohol metabolism.

Intervention Type DIETARY_SUPPLEMENT

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Habitual alcohol consumer (average 1-14 units per week)
* BMI 18.5 - 29.9 kg/m2
* Be able to attend the laboratory and willing to participate in necessary protocols
* Be willing to undertake the durations of the exercise protocol (2 hours) \]
* Have the capacity and willingness to provide informed consent (oral and written)

Exclusion Criteria

* Non-or excessive alcohol drinkers (0 or \>14 units per week)
* History of substance abuse
* Habitual/previously habitual smokers
* BMI \>30.0 kg/m2
* Experience contraindications to the administration of the proposed anaesthetic (Lidocaine Hydrochloride)

Minimum Eligible Age

18 Years

Maximum Eligible Age

30 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes