Working Memory Training for Dysphoric Students

NCT ID: NCT02184481

Last Updated: 2014-07-09

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

94 participants

Study Classification

INTERVENTIONAL

Study Start Date

2013-09-30

Brief Summary

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Depression is associated with impairments in executive functions, including working memory (WM) which is needed to maintain and manipulate goal-relevant information. Due to these WM impairments depressed individuals have difficulties inhibiting and shifting from irrelevant (negative) information and updating goal relevant information. This study explored whether training WM decreases these impairments and reduces clinical symptoms of depression, anxiety and rumination. Sixty-one students with an elevated score on the BDI-II, representing a dysphoric mood state, executed a working memory training (n = 34) or placebo training (n = 27). Before and after training their depression, anxiety, rumination and working memory were assessed. Furthermore, they executed a working memory task while their pupil dilation was measured to assess their fatigue. Moreover, the investigators compared the dysphoric students with a healthy student population on all measures.

Detailed Description

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Conditions

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Depression

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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Working memory training

Participants executed the training for three weeks, three times a week, half an hour per session. The training was a game in which the participant was a person who had to become strong to fight with a fantasy figure. The person could become stronger when giving the right answers in eight different working memory tasks. The level adapted to the working memory capacity of the participant.

Group Type EXPERIMENTAL

Working memory training

Intervention Type BEHAVIORAL

Placebo training

Participants executed the training for three weeks, three times a week, half an hour per session. The training was a game in which the participant was a person who had to become strong to fight with a fantasy figure. The person could become stronger when giving the right answers in eight different working memory tasks. The level in the placebo condition was easy and did not adapt to the working memory capacity of the participant.

Group Type PLACEBO_COMPARATOR

Placebo training

Intervention Type BEHAVIORAL

Interventions

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Working memory training

Intervention Type BEHAVIORAL

Placebo training

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* BDI 10 of higher for dysphoric group
* BDI 5 or lower for healthy control group
Minimum Eligible Age

17 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Erasmus Medical Center

OTHER

Sponsor Role lead

Responsible Party

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Ingmar Franken

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Erasmus University Rotterdam

Rotterdam, South Holland, Netherlands

Site Status

Countries

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Netherlands

References

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Hopstaken JF, Wanmaker S, van der Linden D, Bakker AB. Does Dysphoria Lead to Divergent Mental Fatigue Effects on a Cognitive Task? PLoS One. 2015 Jun 15;10(6):e0130304. doi: 10.1371/journal.pone.0130304. eCollection 2015.

Reference Type DERIVED
PMID: 26075389 (View on PubMed)

Other Identifiers

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Franken 5

Identifier Type: -

Identifier Source: org_study_id

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