Effect of Pre-injection of Lidocaine on Myoclonus Induced by Induction With Etomidate in Elderly Patients During General Anesthesia
NCT ID: NCT02141737
Last Updated: 2014-05-19
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
PHASE4
272 participants
INTERVENTIONAL
2014-05-31
2014-10-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
DOUBLE
Study Groups
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Group C
Induction protocol: patients will be given 2 ml normal saline solution, 1 minutes later, 0.3 mg/kg etomidate is injected within 30 to 60 s, and 90 s after the injection of etomidate, 0.2 mg/kg midazolam, 3 μg/kg fentanyl, 0.6 mg/kg rocuronium are given sequently.
Etomidate Fat Emulsion Injection
1 minute after the injection of lidocaine, 0.3 mg/kg etomidate will be given in 30 to 60 s.
normal saline
2 ml normal saline will be given 1 minute before the injection of etomidate in patients in group C, and in group L1 and L2, normal saline is used to dilute lidocaine injection to 2 ml.
Midazolam Injection
0.02 mg/kg midazolam will be given to the patients in all groups 90 s after the injection of etomidate.
Fentanyl Citrate Injection
3 μg/kg fentanyl will be given to patients in all groups after the injection of midazolam.
Rocuronium Injection
0.6 mg/kg rocuronium will be given to patients in all groups after the injection of fentanyl.
Group L1
Induction protocol: patients will be given 2 ml diluted lidocaine injection in which 20 mg lidocaine is contained, 1 minutes later, 0.3 mg/kg etomidate is injected within 30 to 60 s, and 90 s after the injection of etomidate, 0.2 mg/kg midazolam, 3 μg/kg fentanyl, 0.6 mg/kg rocuronium are given sequently.
Lidocaine Hydrochloride Injection
Lidocaine injection should be give before the injection of etomidate. In groups L1 and L2, 20 mg and 30 mg lidocaine injection will be diluted to 2ml separately.
Etomidate Fat Emulsion Injection
1 minute after the injection of lidocaine, 0.3 mg/kg etomidate will be given in 30 to 60 s.
normal saline
2 ml normal saline will be given 1 minute before the injection of etomidate in patients in group C, and in group L1 and L2, normal saline is used to dilute lidocaine injection to 2 ml.
Midazolam Injection
0.02 mg/kg midazolam will be given to the patients in all groups 90 s after the injection of etomidate.
Fentanyl Citrate Injection
3 μg/kg fentanyl will be given to patients in all groups after the injection of midazolam.
Rocuronium Injection
0.6 mg/kg rocuronium will be given to patients in all groups after the injection of fentanyl.
Group L2
Induction protocol: patients will be given 2 ml diluted lidocaine injection in which 30 mg lidocaine is contained, 1 minutes later, 0.3 mg/kg etomidate is injected within 30 to 60 s, and 90 s after the injection of etomidate, 0.2 mg/kg midazolam, 3 μg/kg fentanyl, 0.6 mg/kg rocuronium are given sequently.
Lidocaine Hydrochloride Injection
Lidocaine injection should be give before the injection of etomidate. In groups L1 and L2, 20 mg and 30 mg lidocaine injection will be diluted to 2ml separately.
Etomidate Fat Emulsion Injection
1 minute after the injection of lidocaine, 0.3 mg/kg etomidate will be given in 30 to 60 s.
normal saline
2 ml normal saline will be given 1 minute before the injection of etomidate in patients in group C, and in group L1 and L2, normal saline is used to dilute lidocaine injection to 2 ml.
Midazolam Injection
0.02 mg/kg midazolam will be given to the patients in all groups 90 s after the injection of etomidate.
Fentanyl Citrate Injection
3 μg/kg fentanyl will be given to patients in all groups after the injection of midazolam.
Rocuronium Injection
0.6 mg/kg rocuronium will be given to patients in all groups after the injection of fentanyl.
group L3
Induction protocol: patients will be given 2 ml lidocaine injection in which 40 mg lidocaine is contained, 1 minutes later, 0.3 mg/kg etomidate is injected within 30 to 60 s, and 90 s after the injection of etomidate, 0.2 mg/kg midazolam, 3 μg/kg fentanyl, 0.6 mg/kg rocuronium are given sequently.
Lidocaine Hydrochloride Injection
Lidocaine injection should be give before the injection of etomidate. In groups L1 and L2, 20 mg and 30 mg lidocaine injection will be diluted to 2ml separately.
Etomidate Fat Emulsion Injection
1 minute after the injection of lidocaine, 0.3 mg/kg etomidate will be given in 30 to 60 s.
Midazolam Injection
0.02 mg/kg midazolam will be given to the patients in all groups 90 s after the injection of etomidate.
Fentanyl Citrate Injection
3 μg/kg fentanyl will be given to patients in all groups after the injection of midazolam.
Rocuronium Injection
0.6 mg/kg rocuronium will be given to patients in all groups after the injection of fentanyl.
Interventions
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Lidocaine Hydrochloride Injection
Lidocaine injection should be give before the injection of etomidate. In groups L1 and L2, 20 mg and 30 mg lidocaine injection will be diluted to 2ml separately.
Etomidate Fat Emulsion Injection
1 minute after the injection of lidocaine, 0.3 mg/kg etomidate will be given in 30 to 60 s.
normal saline
2 ml normal saline will be given 1 minute before the injection of etomidate in patients in group C, and in group L1 and L2, normal saline is used to dilute lidocaine injection to 2 ml.
Midazolam Injection
0.02 mg/kg midazolam will be given to the patients in all groups 90 s after the injection of etomidate.
Fentanyl Citrate Injection
3 μg/kg fentanyl will be given to patients in all groups after the injection of midazolam.
Rocuronium Injection
0.6 mg/kg rocuronium will be given to patients in all groups after the injection of fentanyl.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
60 Years
81 Years
ALL
No
Sponsors
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Tang-Du Hospital
OTHER
Responsible Party
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Locations
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TangDu Hospital,FMMU
Xi’an, Shanxi, China
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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20140514
Identifier Type: -
Identifier Source: org_study_id
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