Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
192 participants
INTERVENTIONAL
2018-11-10
2019-11-10
Brief Summary
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Detailed Description
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Conditions
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Keywords
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Study Design
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RANDOMIZED
PARALLEL
PREVENTION
TRIPLE
Study Groups
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deep neuromuscular blockade
Rocuronium, a neuromuscular blocking agent will be given by continuous infusion at a dose that reaction to train of four (TOF) stimulation is depressed to zero
Rocuronium
rocuronium is a neuromuscular blocking agent with a duration of 40 minutes
continuous infusion
rocuronium is continuously infused
moderate neuromuscular blockade
Rocuronium, a neuromuscular blocking agent will be given at a dose by intermittent injection that reaction to train of four (TOF) stimulation is kept 1 to 2
Rocuronium
rocuronium is a neuromuscular blocking agent with a duration of 40 minutes
intermittent injection
rocuronium is intermittently given
Interventions
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Rocuronium
rocuronium is a neuromuscular blocking agent with a duration of 40 minutes
continuous infusion
rocuronium is continuously infused
intermittent injection
rocuronium is intermittently given
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* American Society of Anesthesiologists status 1-2
* Body mass index of 18-30kg/m2
* Patients scheduled to be positioned in trendelenburg position during surgery
Exclusion Criteria
* Patients with neuromuscular dysfunction
* Patients with existed pulmonary diseases
* Patients with hepatic or renal dysfunction
18 Years
80 Years
ALL
No
Sponsors
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Air Force Military Medical University, China
OTHER
Responsible Party
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Zhihong LU
principle investigator
Principal Investigators
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Zhihong Lu
Role: PRINCIPAL_INVESTIGATOR
Xijing Hospital
Central Contacts
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References
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Van Wijk RM, Watts RW, Ledowski T, Trochsler M, Moran JL, Arenas GW. Deep neuromuscular block reduces intra-abdominal pressure requirements during laparoscopic cholecystectomy: a prospective observational study. Acta Anaesthesiol Scand. 2015 Apr;59(4):434-40. doi: 10.1111/aas.12491. Epub 2015 Feb 13.
Martini CH, Boon M, Bevers RF, Aarts LP, Dahan A. Evaluation of surgical conditions during laparoscopic surgery in patients with moderate vs deep neuromuscular block. Br J Anaesth. 2014 Mar;112(3):498-505. doi: 10.1093/bja/aet377. Epub 2013 Nov 15.
Barrio J, Errando CL, Garcia-Ramon J, Selles R, San Miguel G, Gallego J. Influence of depth of neuromuscular blockade on surgical conditions during low-pressure pneumoperitoneum laparoscopic cholecystectomy: A randomized blinded study. J Clin Anesth. 2017 Nov;42:26-30. doi: 10.1016/j.jclinane.2017.08.005. Epub 2017 Aug 30.
Torensma B, Martini CH, Boon M, Olofsen E, In 't Veld B, Liem RS, Knook MT, Swank DJ, Dahan A. Deep Neuromuscular Block Improves Surgical Conditions during Bariatric Surgery and Reduces Postoperative Pain: A Randomized Double Blind Controlled Trial. PLoS One. 2016 Dec 9;11(12):e0167907. doi: 10.1371/journal.pone.0167907. eCollection 2016.
Other Identifiers
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XJH-A-20180701
Identifier Type: -
Identifier Source: org_study_id