A Follow-up Study for a Phase III, Efficacy Trial in Inactivated Enterovirus Type 71 (EV71) Vaccine

NCT ID: NCT02001233

Last Updated: 2022-05-26

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

10077 participants

Study Classification

OBSERVATIONAL

Study Start Date

2013-03-31

Study Completion Date

2014-10-31

Brief Summary

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The purpose of this follow-up study is to evaluate the two-year efficacy, immunogenicity and safety of EV71 Vaccines in preventing Hand, Foot and Mouth disease caused by EV71 in a total 10,000 healthy infants volunteers aged from 6 to 35months old.

Detailed Description

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The phase III, efficacy trial of inactivated vaccine (vero cell) against EV71 has completed on March 2013 in China. The data from the phase III study suggested that the inactivated EV71 vaccine had protection effects on healthy Chinese infants against Hand, Foot and Mouth disease caused by EV71 within one-year surveillance period, and had clinically acceptable safety and good one-year immune persistence.

This study is the phase III, open-labelled, follow-up research, in order to evaluate the two-year efficacy, safety and immune persistence.

Conditions

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Hand, Foot and Mouth Disease

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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EV71 Vaccine

Inactivated vaccine (vero cell) against EV71 of 400U /0.5ml in 5000 infants aged 6-35 months old on day0,28

EV71 vaccine

Intervention Type BIOLOGICAL

inactivated vaccine (vero cell) against EV71 of 400U /0.5ml, two doses, 28 days interval

Placebo

placebo in 5000 infants aged 6-35 months old on day0,28

No interventions assigned to this group

Interventions

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EV71 vaccine

inactivated vaccine (vero cell) against EV71 of 400U /0.5ml, two doses, 28 days interval

Intervention Type BIOLOGICAL

Eligibility Criteria

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Inclusion Criteria

* All subjects vaccinated at least one injection of EV71 vaccine or the placebo in the phase III efficacy trial.

Exclusion Criteria

* subjects who refuse to continue in the study.
Minimum Eligible Age

6 Months

Maximum Eligible Age

35 Months

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Sinovac Biotech Co., Ltd

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Feng-Cai Zhu, BS

Role: PRINCIPAL_INVESTIGATOR

Jiangsu Center for Diseases Control and Prevention

Locations

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Ganyu

Lianyungang, Jiangsu, China

Site Status

Taixing

Taizhou, Jiangsu, China

Site Status

Sheyang

Yancheng, Jiangsu, China

Site Status

Countries

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China

Other Identifiers

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PRO-EV71-3003-0

Identifier Type: -

Identifier Source: org_study_id

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