Predisposition to Persistent Pain After Orthopaedic Surgery: Genetic Aspects

NCT ID: NCT01989351

Last Updated: 2017-02-07

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Total Enrollment

130 participants

Study Classification

OBSERVATIONAL

Study Start Date

2013-03-31

Study Completion Date

2017-02-06

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The study purpose is to examine polymorphism of genes associated to post-operative persistent pain and to verify the possible association between genotype phenotype and ADRB2 polymorphism in orthopaedic surgery. The primary aim is to evaluate the expression of ADBR2 in VAS\>4 patients and to compare it to those with VAS\<4.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Chronic Pain

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

VAS<4

No interventions assigned to this group

VAS>4

No interventions assigned to this group

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* age \> 18
* ASA I to III

Exclusion Criteria

* Contraindications to regional anesthesia procedures
* Not stabilized neurological diseases
* Diabetes
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

ASST Gaetano Pini-CTO

OTHER

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Gianluca Cappelleri

Medical Doctor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

Gianluca Cappelleri, MD

Role: PRINCIPAL_INVESTIGATOR

ASST Gaetano Pini-CTO

Manuela de Gregori, Biologist

Role: STUDY_CHAIR

Fondazione IRCCS Policlinico San Matteo di Pavia

Massimo Allegri, M.D.

Role: STUDY_CHAIR

Fondazione IRCCS Policlinico San Matteo di Pavia

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Istituto Ortopedico G. Pini

Milan, Milano, Italy

Site Status

Countries

Review the countries where the study has at least one active or historical site.

Italy

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

IOGPGC03-13

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.

Chronic Pain After Operation for Breast Cancer
NCT00739544 UNKNOWN EARLY_PHASE1
Multimodal and Unimodal Analgesia in Cholecystectomy
NCT05547659 COMPLETED PHASE1/PHASE2