Evaluation of Pharmacogenetic Factors Affecting Fentanyl Requirements for Postoperative Pain Control

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

204 participants

Study Classification

OBSERVATIONAL

Study Start Date

2008-09-30

Study Completion Date

2012-12-31

Brief Summary

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Fentanyl is a widely used opioid analgesic. There are big interindividual variabilities in dose requirements of fentanyl for postoperative pain control. This study aims to reveal the genetic factors affecting the variable requirements of fentanyl during postoperative period.

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Detailed Description

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The candidate genes are OPRM1, ABCB1,CYP3A4 and CYP3A5.

Conditions

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Pain, Postoperative

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* Patients undergoing total abdominal hysterectomy (TAH) or laparoscopy assisted vaginal hysterectomy (LAVH) under general anesthesia
* Patients who want to use intravenous patient controlled analgesia (PCA) after surgery
* ASA physical status class I, II

Exclusion Criteria

* history of drug addiction
* opioid medication within 12 hours before surgery
* previous history of opioid medication for 3 months
* neurologic disorder
* cardiac disorder
* hepatic disease
* renal disease
* respiratory disease such as COPD, asthma
* sleep apnea
* BMI \> 30
* psycotic disorder

Minimum Eligible Age

19 Years

Maximum Eligible Age

65 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No