Genetic Variants and Postoperative Pain

NCT ID: NCT03489499

Last Updated: 2026-01-07

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

5000 participants

Study Classification

OBSERVATIONAL

Study Start Date

2011-01-02

Study Completion Date

2027-04-30

Brief Summary

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Prospective observational study to analyse patients' pain related outcome after surgery and ist association to genetic variants and non-genetic variables.

Detailed Description

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Background

Severe acute pain as well as long-lasting pain after surgery and pain-related interference of daily activities are frequent. Some risk factors for severe pain after surgery in adults have been described, e.g. younger age and pre-existing chronic pain. The question arises whether a specific genetic background is related to an unfavorable pain outcome.

Objective

The aim of this study is to investigate clinical and genetic variables and their possible association to severe acute postoperative pain, higher analgesic consumption and the development of chronic postsurgical pain.

Methods

Prospective observational study investigating clinical, patient related, surgery related and anesthesia related variables as well as genetic variants and their possible association to patients' pain related outcome after surgery.

Conditions

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Postoperative Pain Analgesia Surgical Procedure, Operative

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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All patients

Patients undergoing elective surgery with anesthesia

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* 18 years and older
* Written informed consent
* Elective surgery
* Patients' ability to understand the purpose of the study

Exclusion Criteria

* No informed consent
* Cognitive impairment
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Insel Gruppe AG, University Hospital Bern

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Ulrike Stamer, Prof. MD

Role: STUDY_CHAIR

Department of Anaestheisolpogy + Pain Medicine, Inselspital, University of Bern

Ulrike M Stamer, MD

Role: PRINCIPAL_INVESTIGATOR

Department of Anaesthesiology and Pain Medicine, Inselspital, University of Bern

Locations

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Department of Anaesthesiology and Pain Medicine, Inselspital, University of Bern

Bern, , Switzerland

Site Status RECRUITING

Countries

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Switzerland

Central Contacts

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Ulrike M Stamer, Prof. MD

Role: CONTACT

0041-316329995

Frank Stüber, Prof. MD

Role: CONTACT

0041-316322483

Facility Contacts

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Ulrike Stamer, Professor MD

Role: primary

041-316329995

Lan Zhang, PhD

Role: backup

0041-316328872

Other Identifiers

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041/09c Schmerz

Identifier Type: -

Identifier Source: org_study_id

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