The Possible Correlations Between the Genes Related to Pain Sensation and the Pain Sensitivity in the General Population

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

View full results

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Total Enrollment

1533 participants

Study Classification

OBSERVATIONAL

Study Start Date

2013-08-31

Study Completion Date

2014-12-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Objective: This study was conducted to explore the possible correlation between some gene related to pain sensation and individual basal pain perception and postoperative pain intensity in the general population. Methods: Patients receiving elective surgery under general anesthesia were recruited into this study. The investigators measured their preoperative pressure pain threshold (PPT) and pressure pain tolerance (PTO). Pain intensity at rest and movement after the operation was evaluated . And the PCA drug consumption were recorded. Also there were healthy college students volunteer be recruited into this study. The investigators measured their experimental pain sensitivity including pressure pain threshold (PPT) and pressure pain tolerance (PTO), etc. Then genotyping was carried out.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

A Epidemiological Survey of Preoperative Pain Perception and Postoperative Pain in Chinese Population

NCT01750047

Pain Surgery

COMPLETED

Flexibility of Cognition And Persistent Pain

NCT02579538

Pain, Postoperative

COMPLETED

Epigenetic Influences on Post-Surgical Acute and Chronic Pain

NCT02002520

Acute Pain

UNKNOWN

The Prediction for Postoperative Pain

NCT03585088

Pain, Postoperative Nociceptive Pain Analgesia, Patient-Controlled +1 more

COMPLETED NA

Effect of Acetaminophen Preemptive Analgesia on Postoperative Cognitive Function

NCT06004687

Cognitive Function

UNKNOWN PHASE1/PHASE2

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Subjects with the following diseases were excluded: known history of chronic disease, psychiatric diseases or communication disorders, diabetes mellitus, severe cardiovascular diseases, kidney or liver diseases with poor hepatic function, alcohol or drug abuse, heavy smoker, Pregnancy or at lactation period .

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Pain Surgery

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Study Time Perspective

PROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

surgical patients

grouped by receiving surgery

No interventions assigned to this group

Healthy volunteers group

grouped by healthy college students

No interventions assigned to this group

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* •Aged 18-65 years

* Receiving elective gynecological laparoscopic surgery
* Anesthesiologists (ASA) physical status I or II
* Agreed to participate the research

Exclusion Criteria

* •History of chronic pain

* Psychiatric diseases
* Diabetes mellitus
* Severe cardiovascular diseases
* Kidney or liver diseases
* Alcohol or drug abuse
* Heavy smoker
* Pregnancy or at lactation period
* Disagree to participate to the research

Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes