Efficacy of Propofol or Midazolam Compare to Placebo for Preoperative Medication

NCT ID: NCT01976845

Last Updated: 2016-03-14

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: PHASE4
• Total Enrollment: 139 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2013-11-30
• Study Completion Date: 2015-07-31

Brief Summary

The purpose of this research is:

To evaluate the sedative (reduces irritability or agitation), anxiolytic (reduces anxiety), and amnesic (produces temporary lack of recall) effects of propofol or midazolam when administered for preoperative medication (before administration of drugs that will put patient to sleep) in comparison to placebo. This study is to test whether the use of the pre-anesthesia medication measurably reduces anxiety in comparison to receiving no pre-anesthesia medication prior to orthopedic procedures.

To assess the effect of propofol in comparison to placebo and midazolam on the ability to recall (memory of):

• when the doctor places the mask on patient's face prior to going to sleep
• recall of 2 pictures
• on your satisfaction with the anesthesia as well as postoperative side effects in post-anesthesia care unit (PACU) e.g., nausea ,vomiting and sedation.

Detailed Description

The role of anxiolytic premedication in the ambulatory surgical population is frequently debated. Anesthesiologists may consider the administration of anxiety-reducing drugs unnecessary when anxiety levels are low in outpatients presenting for minor surgery. However, the previous study reports that up to 80% of outpatients expressed a preference for a combination of anxiety-reducing and hypnotic premedication before surgery (1-4). In addition to anxiolysis, goals of anxiolytic premedication include sedation, amnesia, improved patient cooperation, and/or improved patient satisfaction. Intravenous (IV) midazolam is the most commonly used premedicant in the ambulatory setting due to its rapid onset, and short half-life (2,3,5), but its residual effects in the immediate postoperative period may contribute to postoperative sedation, as well as to delayed recovery and discharge-readiness after brief outpatient surgery. Furthermore, White et al. (6) noted that the slope of the dose-response curve for sedation was much steeper with midazolam compared with diazepam, which suggests that midazolam may possess a smaller margin of safety and greater need for careful titration to achieve the desired clinical end-point without untoward side effects.

Propofol has become the IV (intravenous) anesthetic of choice for ambulatory anesthesia because of its excellent recovery profile (7). Clinical experience with propofol in the ambulatory setting suggests that its use is associated with less residual sedation and lower incidence of postoperative nausea and vomiting (PONV) (8). However, there are some undesirable side effects associated with propofol including pain on injection, cardiovascular and respiratory depression, and occasional excitement on emergence from anesthesia (9). Practically, small doses of propofol (10-20 mg IV) have been used as an anxiolytic/sedative medication.

To date, there is only one study that has evaluated propofol versus midazolam versus placebo as premedication (10). In this study, the authors stated that propofol (0.4 mg/kg IV) had anxiolytic effects comparable in magnitude and duration to midazolam (0.04 mg/kg IV) with less memory impairment, respiratory depression and dizziness. However, they did not assess the efficacy of propofol and midazolam as a premedication on the recovery profiles and patient's satisfaction in their study. Compared to placebo and propofol, midazolam was associated with more frequent respiratory depression and significant impairment of anterograde explicit memory. Both propofol and midazolam helped relieve anxiety and lowered blood pressure (compared to baseline) but both were associated with greater dizziness scores (P<0.001, compared to placebo).

They concluded that Propofol had an anxiolytic effect comparable in magnitude and duration to that of midazolam with less memory impairment, respiratory depression and dizziness.

Propofol appears to be an economical, effective and safe alternative to midazolam for treating pre-anesthesia anxiety, and especially to be used for induction of anesthesia (10). (This sentence is not clear).

Therefore, we designed this randomized, double-blind, and placebo-controlled study to evaluate propofol as a premedication and to see if it:

• produces comparable anxiolytic effects to midazolam when compared to placebo, but with less memory impairment
• facilitates early recovery profile
• improves patient's satisfaction with the induction and early recovery from anesthesia.

Conditions

Elective Orthopedic Surgery

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: PREVENTION
• Blinding Strategy: QUADRUPLE

Study Groups

Propofol

Propofol 20 mg IV (2 ml)

Group Type: EXPERIMENTAL

Propofol

Intervention Type: DRUG

Propofol (20mg) 2 ml IV, in the pre-op area as a premedication

Midazolam

Midazolam 2 mg IV (2 ml)

Group Type: ACTIVE_COMPARATOR

Midazolam

Intervention Type: DRUG

Midazolam (20mg) 2 ml IV, in the pre-op area as a premedication

Saline

Saline 2 ml

Group Type: PLACEBO_COMPARATOR

Saline

Intervention Type: DRUG

Saline 2 ml IV, in the pre-op area as a premedication

Interventions

Midazolam

Midazolam (20mg) 2 ml IV, in the pre-op area as a premedication

Intervention Type: DRUG

Propofol

Propofol (20mg) 2 ml IV, in the pre-op area as a premedication

Intervention Type: DRUG

Saline

Saline 2 ml IV, in the pre-op area as a premedication

Intervention Type: DRUG

Other Intervention Names

VERSED; Diprivan; Saline solution

Eligibility Criteria

Inclusion Criteria

• Willingness and ability to sign an informed consent document
• No allergies to midazolam or propofol
• 18 - 70 years of age
• American Society of Anesthesiologists (ASA) Class I-III adults of either sex

Exclusion Criteria

• Patients with known allergy, hypersensitivity or contraindications to midazolam, propofol, anesthetic or analgesic medications
• Patients with clinically-significant medical conditions, such as brain, heart, kidney, endocrine, or liver diseases
• Pregnant or lactating women
• Subjects with a history of alcohol or drug abuse within the past 3 months
• Patients chronically using sedative, anxiolytic drugs prior to the surgery
• Morbid obesity (BMI >40 kg/m2)
• Patients who are agitated or confused prior to receiving the drug ( verbal rating scale [VRS] greater then 6)

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 70 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Cedars-Sinai Medical Center

OTHER

Sponsor Role: lead

Responsible Party

Ronald Wender

Chairman, Department of anesthesiology

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Ronald H Wender, MD

Role: PRINCIPAL_INVESTIGATOR

Cedars-Sinai Medical Center

Locations

Cedars Sinai Medical center

Los Angeles, California, United States

Countries

United States

Other Identifiers

Pro00025204

Identifier Type: -

Identifier Source: org_study_id