Incidence of Postoperative Ketosis and Metabolic Acidosis

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

UNKNOWN

Total Enrollment

100 participants

Study Classification

OBSERVATIONAL

Study Start Date

2012-10-31

Study Completion Date

2013-08-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The aim of this study is to define the incidence and nature of acidosis after major surgery using Figge's equations to directly measure acidosis. This study will also aim to compare the ability of indirect measures (base deficit, anion gap,corrected anion gap and lactate) to identify the presence of tissue acids in this population. The incidence of postoperative ketoacidosis as a contributor to tissue acidosis will be assessed through the use of point of care urinalysis.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Development of Ketoacidosis During the Perioperative Period: an Observational Study 'The DKAP Study'

NCT05225467

Ketosis Keto Acidosis Ketoses, Metabolic +3 more

COMPLETED

Intraoperative Cell Salvage and Postoperative Acidosis

NCT02800343

Metabolic Acidosis

COMPLETED

Hyperlactacidemia in Major Abdominal Surgery and Monocarboxylate Receptors

NCT06222021

Surgical Procedure, Unspecified Postoperative Complications Hyperlactatemia +1 more

NOT_YET_RECRUITING NA

Effect of Urine-guided Hydration on Acute Kidney Injury After CRS-HIPEC

NCT05939193

Cytoreductive Surgery Hyperthermic Intraperitoneal Chemotherapy Hydration +3 more

COMPLETED NA

The Effect of Perioperative Medications on the Outcomes of Patients Undergoing Cardiac Surgery

NCT01683448

Cardiac Diseases

COMPLETED

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Metabolic acidosis is a frequent occurrence following major surgery. Monitoring acid base disturbances and in particular diagnosing the aetiology of the acidosis are important parts of assessing a patient's cardiovascular status following surgery. The presence of a metabolic acidosis is frequently attributed to anaerobic metabolism leading to the generation of lactic acid due to hypovolaemia and poor tissue perfusion. This commonly results in clinicians treating postoperative patients with a metabolic acidosis by administering intravenous fluids containing 0.9% saline or Hartmann's solution (compound sodium lactate). If the cause of the metabolic acidosis is not hypovolaemia, treatment with intravenous fluids may actually exacerbate the acidosis by causing hyperchloraemia. An often overlooked cause of metabolic acidosis after surgery is starvation leading to ketoacidosis. All patients are starved for a minimum of six hours prior to general anaesthesia due to the potential risk of aspiration of gastric contents into the bronchial tree. Many patients are in fact fasted for much longer periods than this. There is, however, little data describing the incidence of ketoacidosis following surgery. In addition, there may be other causes of acidosis after surgery which often overlooked but can be determined using equations and mathematical models. The aim of this study is to define the incidence and nature of acidosis after major cancer surgery using using equations to directly determine acids. This study will also aim to compare the ability of commonly used indirect measures (base deficit, anion gap, corrected anion gap and lactate) to identify the presence of tissue acids in this population. The incidence of postoperative ketoacidosis as a contributor to tissue acidosis will be assessed through the use of point of care urinalysis.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Metabolic Acidosis

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Patients who have undergone major cancer surgery
* Patients who have an arterial line in place
* Patients who have a urinary catheter in place
* Patients who will be admitted to intensive care following surgery
* Adults \>18 years
* Adults who are capable of reading and understanding English

Exclusion Criteria

* Patient refusal
* Patients without an arterial line or urinary catheter in place
* Patients receiving glucose / sliding scale insulin for management of diabetes mellitus

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No