Influence of High Intensity Exercise on Insulin Resistance, Muscle Contractile Properties, Aerobic Capacity and Body Composition in Multiple Sclerosis
NCT ID: NCT01845896
Last Updated: 2014-05-06
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
34 participants
INTERVENTIONAL
2013-03-31
2014-03-31
Brief Summary
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It is assumed that the the above mentioned clinical parameters will improve due to physical exercise.
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
NONE
Study Groups
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Combined exercise
12 weeks combined exercise programme (supervised)
Training
High intensity interval training
12 weeks high intensity interval exercise programme (supervised)
Training
Control
sedentary/habitual lifestyle
No interventions assigned to this group
Interventions
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Training
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Expanded Disability Status Scale (EDSS) between 0.5 and 6
* Be able to train 5 times in 2 weeks at the University
Exclusion Criteria
* Having had an relapse in a period of 3 months prior to the start of the intervention period
* Having an relapse during the intervention period
* Pregnancy and other contra indications for physical activity
* Mental disorders
18 Years
65 Years
ALL
Yes
Sponsors
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Bert Op't Eijnde
OTHER
Responsible Party
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Bert Op't Eijnde
Ph.D
Principal Investigators
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Inez Wens, M.Sc.
Role: PRINCIPAL_INVESTIGATOR
Reval/Biomed, Hasselt University
Bert Opt Eijnde, Ph.D
Role: STUDY_CHAIR
Reval/Biomed, Hasselt University
Locations
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Reval
Diepenbeek, , Belgium
Countries
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References
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Wens I, Dalgas U, Vandenabeele F, Grevendonk L, Verboven K, Hansen D, Eijnde BO. High Intensity Exercise in Multiple Sclerosis: Effects on Muscle Contractile Characteristics and Exercise Capacity, a Randomised Controlled Trial. PLoS One. 2015 Sep 29;10(9):e0133697. doi: 10.1371/journal.pone.0133697. eCollection 2015.
Hansen D, Wens I, Vandenabeele F, Verboven K, Eijnde BO. Altered signaling for mitochondrial and myofibrillar biogenesis in skeletal muscles of patients with multiple sclerosis. Transl Res. 2015 Jul;166(1):70-9. doi: 10.1016/j.trsl.2015.01.006. Epub 2015 Jan 20.
Wens I, Dalgas U, Vandenabeele F, Krekels M, Grevendonk L, Eijnde BO. Multiple sclerosis affects skeletal muscle characteristics. PLoS One. 2014 Sep 29;9(9):e108158. doi: 10.1371/journal.pone.0108158. eCollection 2014.
Other Identifiers
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13.20/reva13.02
Identifier Type: -
Identifier Source: org_study_id
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