Genetic Variability in Taste Perception

NCT ID: NCT01841710

Last Updated: 2016-03-16

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

90 participants

Study Classification

OBSERVATIONAL

Study Start Date

2012-12-31

Study Completion Date

2015-12-31

Brief Summary

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This proposal describes a pilot study aimed at determining whether genetic variations in taste receptors determine differential taste tolerability of pediatric medications.

Detailed Description

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This is a cross-sectional call-back study of taste perception and the relationship between taste perception and taste receptor genotype.

Conditions

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Healthy

Study Design

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Observational Model Type

COHORT

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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Women

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Adult females who were previously enrolled in Efficacy of Bitter Blockers on Taste Acceptance in Pediatric Populations Study (Protocol #809789)

Exclusion Criteria

* Women who are pregnant
* Women on drugs with potential serious adverse effects that are mediated through cytochrome P450.
Minimum Eligible Age

18 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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Children's Hospital of Philadelphia

OTHER

Sponsor Role collaborator

University of Pennsylvania

OTHER

Sponsor Role collaborator

National Institute on Deafness and Other Communication Disorders (NIDCD)

NIH

Sponsor Role collaborator

Monell Chemical Senses Center

OTHER

Sponsor Role lead

Responsible Party

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Julie A. Mennella

Member

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Julie A. Mennella, PhD

Role: PRINCIPAL_INVESTIGATOR

Monell Chemical Senses Center

Elizabeth Lowenthal, MD MSCE

Role: PRINCIPAL_INVESTIGATOR

University of Pennsylvania

Locations

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Monell Chemical Senses Center

Philadelphia, Pennsylvania, United States

Site Status

Countries

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United States

References

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Mennella JA, Mathew PS, Lowenthal ED. Use of Adult Sensory Panel to Study Individual Differences in the Palatability of a Pediatric HIV Treatment Drug. Clin Ther. 2017 Oct;39(10):2038-2048. doi: 10.1016/j.clinthera.2017.08.012. Epub 2017 Sep 18.

Reference Type DERIVED
PMID: 28923290 (View on PubMed)

Other Identifiers

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R01DC011287

Identifier Type: NIH

Identifier Source: secondary_id

View Link

816980

Identifier Type: -

Identifier Source: org_study_id

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