Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.
RECRUITING
5000 participants
OBSERVATIONAL
2018-08-01
2027-12-31
Brief Summary
Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.
Related Clinical Trials
Explore similar clinical trials based on study characteristics and research focus.
Genetic Architecture of Chronic Inflammatory Demyelinating Polyradiculoneuropathy
NCT06325878
Observational Study Linking Genetic Variants With Clinical Outcomes in Pain Management
NCT02480075
Pharmacogenetic Testing and Chronic Pain
NCT05259865
Study to Identify the Genetic Variations Associated With Phantom Limb Pain
NCT01462448
Pain Predict Genetics
NCT02383342
Detailed Description
Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.
Peripheral nerve lesions only progress to neuropathic pain in some patients, yet is not completely understood why or how. Genetic studies of patients with rare neuropathic disorders have been important for elucidating novel molecular mechanisms of neuropathic pain, and new drugs for neuropathic pain are now being developed based on these findings. By using genetic association studies, one may identify new genetic variants which may help to identify key molecular mechanisms for a larger group of patients with neuropathic pain.
This project will use existing population-based cohorts, as well as establish a specific registry and biobank for patients with neuropathy in order to address these specific needs. This will allow the investigators to identify a large number of individuals with probable neuropathic pain and individuals with pain-free peripheral neuropathy (disease controls). International collaboration will contribute to study a large group of patients, which will be important in order to reach the project's goals. The results from the project are expected to increase current knowledge on the mechanisms of neuropathic pain, opening up new opportunities for innovative and improved treatments.
Dissemination of results will be organized in close collaboration with patient representatives, and will be done regularly throughout the course of the project. The will focus both on internal dissemination to the participating hospitals, and external dissemination through participation in conferences, submissions to scientific journals and by publishing patient-friendly information booklets and proactively informing media outlets and patient organizations.
Conditions
See the medical conditions and disease areas that this research is targeting or investigating.
Study Design
Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.
CASE_CONTROL
CROSS_SECTIONAL
Study Groups
Review each arm or cohort in the study, along with the interventions and objectives associated with them.
Polyneuropathy with pain
Clinical and diagnostic test evaluation for the establishment of polyneuropathy with pain.
Nerve conduction Studies
Patients will be genotyped for comparison of patients With and without pain, With different clinical subgroups as mentioned.
Polyneuropathy without pain
Clinical and diagnostic test evaluation for the establishment of polyneuropathy without pain.
Nerve conduction Studies
Patients will be genotyped for comparison of patients With and without pain, With different clinical subgroups as mentioned.
Diabetic polyneuropathy with pain
Clinical and diagnostic test evaluation for the establishment of diabetic polyneuropathy with pain.
Nerve conduction Studies
Patients will be genotyped for comparison of patients With and without pain, With different clinical subgroups as mentioned.
Diabetic polyneuropathy without pain
Clinical and diagnostic test evaluation for the establishment of diabetic polyneuropathy without pain.
Nerve conduction Studies
Patients will be genotyped for comparison of patients With and without pain, With different clinical subgroups as mentioned.
Carpal tunnel syndrome with pain
Clinical and diagnostic test evaluation for the establishment of carpal tunnel syndrome with pain.
Nerve conduction Studies
Patients will be genotyped for comparison of patients With and without pain, With different clinical subgroups as mentioned.
Carpal tunnel syndrome without pain
Clinical and diagnostic test evaluation for the establishment of carpal tunnel syndrome without pain.
Nerve conduction Studies
Patients will be genotyped for comparison of patients With and without pain, With different clinical subgroups as mentioned.
Interventions
Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.
Nerve conduction Studies
Patients will be genotyped for comparison of patients With and without pain, With different clinical subgroups as mentioned.
Other Intervention Names
Discover alternative or legacy names that may be used to describe the listed interventions across different sources.
Eligibility Criteria
Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.
Inclusion Criteria
2. The patient has consented.
3. The patient is referred for evaluation of possible distal symmetric polyneuropathy (DSPN).
4. The patient has filled out the questionnaires.
Exclusion Criteria
2. The patient is unable to consent (eg. dementia, speech problems, psychiatric disorder).
3. Inflammatory acute polyneuropathy.
18 Years
70 Years
ALL
No
Sponsors
Meet the organizations funding or collaborating on the study and learn about their roles.
Haukeland University Hospital
OTHER
Helse Stavanger HF
OTHER_GOV
St. Olavs Hospital
OTHER
University Hospital of North Norway
OTHER
University of Oxford
OTHER
Danish Pain Research Center
OTHER
Oslo Metropolitan University
OTHER
Oslo University Hospital
OTHER
Responsible Party
Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.
Kristian Bernhard Nilsen
Senior Consultant, phd
Principal Investigators
Learn about the lead researchers overseeing the trial and their institutional affiliations.
John Anker Zwart, M.D.
Role: STUDY_CHAIR
Oslo University Hospital
David Benett, M.D.
Role: PRINCIPAL_INVESTIGATOR
University of Oxford
Ina Hjelland, M.D.
Role: PRINCIPAL_INVESTIGATOR
Haukeland University Hospital
Margreth Grotle, Pr.
Role: PRINCIPAL_INVESTIGATOR
Oslo Metropolitan University
Marie Bu Kvaløy, M.D.
Role: PRINCIPAL_INVESTIGATOR
Helse Stavanger HF
Trond Sand, M.D.
Role: PRINCIPAL_INVESTIGATOR
St. Olavs Hospital
Sissel Løseth, M.D.
Role: PRINCIPAL_INVESTIGATOR
University of North Norway
Troels Jensen, M.D.
Role: PRINCIPAL_INVESTIGATOR
Danish pain research senter
Locations
Explore where the study is taking place and check the recruitment status at each participating site.
Haukeland University Hospital
Bergen, , Norway
Oslo University Hospital
Oslo, , Norway
Helse Stavanger HF
Stavanger, , Norway
University Hospital of North Norway
Tromsø, , Norway
St. Olavs Hospital
Trondheim, , Norway
Countries
Review the countries where the study has at least one active or historical site.
Central Contacts
Reach out to these primary contacts for questions about participation or study logistics.
Facility Contacts
Find local site contact details for specific facilities participating in the trial.
Other Identifiers
Review additional registry numbers or institutional identifiers associated with this trial.
2017/1593
Identifier Type: -
Identifier Source: org_study_id
More Related Trials
Additional clinical trials that may be relevant based on similarity analysis.