Genomic Search for Childhood Obesity Genes-A Pilot Study

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

WITHDRAWN

Study Classification

OBSERVATIONAL

Study Start Date

2007-06-30

Study Completion Date

2008-06-30

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The purpose of this study is to screen a pediatric population (ages 2-8) for genes associated with childhood obesity.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Genetic Analysis of Childhood Obesity

NCT02326480

Obesity

UNKNOWN

Genetic Study of Brain Tumors in Young Children

NCT00010101

Central Nervous System Tumor, Pediatric

TERMINATED

Genetic Testing and Phenotypic Characterization of Severely Obese Pediatric and Adult Volunteers

NCT02849977

Pro-opiomelanocortin (POMC), Proprotein Convertase Subtilisin/Kexin Type 1 (PCSK1) and Leptin Receptor (LepR) Gene Mutations

COMPLETED

Whole-exome Sequencing in Childhood Obesity

NCT02418377

Childhood Obesity

COMPLETED

Genetic and Metabolic Disease in Children

NCT02650622

Genetic Diseases Metabolic Diseases

RECRUITING

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

The incidence of childhood obesity has been growing at an epidemic rate for the past several years, in part due to the lack of understanding of mechanisms at a molecular level. This study will screen a healthy general pediatric population age 2 to 8 for potential genes associated with childhood obesity using whole genomic gene arrays. Patients with BMI values equal to or greater than the 85th percentile will be compared to patients with a BMI below or equal to the 15th percentile. The INSIG2 gene will be specifically studied because of its identification in several populations of obese subjects. The differences in gene expression of the 2 groups will then be used to identify new genes for investigation in childhood obesity.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Obesity

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

OTHER

Study Time Perspective

PROSPECTIVE

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

blood draws

Intervention Type PROCEDURE

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Ages 2-8, predominately Caucasian to minimize population stratification

Exclusion Criteria

* Chronic diseases (diabetes, cancer, etc) and known syndromes

Minimum Eligible Age

2 Years

Maximum Eligible Age

8 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Responsibility Role SPONSOR

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

Merlin G Butler, M.D., Ph.D.

Role: PRINCIPAL_INVESTIGATOR

Children's Mercy Hospital Kansas City

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Children's Mercy Hospital

Kansas City, Missouri, United States

Site Status

Countries

Review the countries where the study has at least one active or historical site.

United States

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

07 03-045E

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.

Association of Genes to Resistance to Weight Loss in Obese Patients

NCT00858221 COMPLETED

Psychosocial Impact of Disclosing Cancer Predisposition Genetic Testing Results During Childhood

NCT04848142 COMPLETED

Studies of Children With Metabolic and Other Genetic Disorders

NCT00025870 COMPLETED

Genetic Study of Sitosterolemia

NCT00004481 COMPLETED

Genetic Study of Insulin-Like Growth Factor-I Receptor Mutations in Patients With Intrauterine Growth Retardation

NCT00005105 UNKNOWN

Educational Video for Genetic Testing

NCT05472714 COMPLETED NA

Investigating the Feasibility and Implementation of Whole Genome Sequencing in Patients With Suspected Genetic Disorder

NCT03829176 COMPLETED NA

Genomics, Single Nucleotide Polymorphisms (SNPs), and Clinical Neonatology

NCT00315263 COMPLETED

Physicians' Understanding of Human Genetic Variation

NCT00339924 COMPLETED

Genetic Study of Newly Diagnosed Central Nervous System Tumors in Young Children

NCT00010114 COMPLETED

Surveying Parents About Genome Screening of Newborns

NCT01736501 WITHDRAWN NA

Genetics of Endocrine Tumours - Familial Isolated Pituitary Adenoma - FIPA

NCT00461188 RECRUITING

The China Neonatal Genomes Project

NCT03931707 RECRUITING

Neurofibromatosis Type 1 Brain Tumor Genetic Risk

NCT01707836 COMPLETED

Identification of Genetic Factors Implicated in Orofacial Cleft Using Whole Exome Sequencing

NCT03065686 UNKNOWN NA

Next Generation to Identify Genetic Causes of Disease in Patients Participating in NICHD Clinical Protocols

NCT01375543 COMPLETED

Transition From Research to Disclosure in Human Genetics

NCT00505466 COMPLETED

Study of the Genome, Gut Metagenome and Diet of Patients With Incident Parkinson's Disease

NCT04119596 TERMINATED

Study of Congenital Orofacial Clefts by Implementing Optical Genome Mapping

NCT06880094 RECRUITING NA

Genetic Causes of Growth Disorders

NCT02311322 TERMINATED

Genetic Data Collection in Adult Participants to Identify Genetic Variants of Known Importance in Non-alcoholic Steatohepatitis (NASH)

NCT05423327 TERMINATED NA

Implementation of Whole Genome Sequencing as Screening in a Diverse Cohort of Healthy Infants

NCT05161169 COMPLETED NA

Finding Genes for Rare Diseases

NCT02724995 WITHDRAWN

Study to Estimate How Common it is to Have Genetic Variants Associated With NAFLD

NCT04494360 COMPLETED

A Pilot Project Exploring the Impact of Whole Genome Sequencing in Healthcare

NCT01736566 COMPLETED NA