Relationship Between Vestibular Function and Topographic Memory

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

50 participants

Study Classification

OBSERVATIONAL

Study Start Date

2013-02-28

Study Completion Date

2013-06-30

Brief Summary

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The purpose of this study is to evaluate visual and nonvisual topographic memory impairment and its relationship to vestibular function in humans. Topographic memory refers to the ability to remember current and past locations in topographic (navigational) space and to make and/or adjust to spatial transformations using such memories. Performance on each of these topographic memory tasks will be compared to performance on a set of comparable nontopographic memory tasks. Topographic impairments represent some of the earliest cognitive deficits observed in Alzheimer's Disease, and the brain areas involved in topographic memory are the first to show degenerative changes.

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Detailed Description

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Conditions

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Normal Elderly Population

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Study Group

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Males or females of all racial and ethnic groups between the ages of 70 and 85 years of age;
* Montreal Cognitive Assessment (MOCA) (http://www.mocatest.org) score of \>24;
* No known history or current evidence of stroke, trauma, psychiatric illness, or other insult to the brain;
* No current use of psychoactive medicine other than caffeine (100 mg/day) or alcohol (1-2 drinks per night);
* Normal sleep (at least an average of 7 hours for four days prior to participation);
* Able and willing to comply with study requirements including following instructions to complete vestibular and neuropsychological testing; and
* Have full understanding of all elements of provide signature and dating of the written informed consent prior to the initiation of procedures specified in protocol.

Exclusion Criteria

* \<70 or \>85 yrs of age;
* MOCA score of \<25;
* History, or current evidence, of stroke, trauma, psychiatric illness, or other insult to the brain;
* Prior history of inner-ear balance problems;
* Current use of psychoactive medicine other than moderate caffeine or alcohol use;
* Acute or chronic sleep deprivation during the week prior to participation (\<7 hours/night on average for four nights prior to participation).

Other Restrictions:

* No alcohol use on the night before the vestibular testing
* 7 hours minimum sleep the night before vestibular testing
* No eye make-up can be worn on the day of the vestibular test due to possible interference with vestibular-ocular reflex testing apparatus

Minimum Eligible Age

70 Years

Maximum Eligible Age

85 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No