Influence of Inspiratory Flow Pattern on Exchange of Carbon Dioxide in Humans Without Primary Lung Disease

NCT ID: NCT01686984

Last Updated: 2015-05-14

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

8 participants

Study Classification

INTERVENTIONAL

Study Start Date

2012-09-30

Study Completion Date

2015-05-31

Brief Summary

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The purpose of this study is to investigate how inspiratory flow pattern influences CO2 elimination in people without primary lung disease.

The hypothesis is that a long mean distribution time, caused by a long postinspiratory pause and high end-inspiratory flow, will promote CO2 exchange in the alveoli.

Detailed Description

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Conditions

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Pulmonary Gas Exchange Carbon Dioxide

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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Altered breath

The group where the investigators alter the inspiratory and expiratory aspects of a ventilated breath.

Group Type EXPERIMENTAL

Altered breath

Intervention Type OTHER

Interventions

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Altered breath

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* No known primary lung disease

Exclusion Criteria

* Primary lung disease
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Region Skane

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Mikael Bodelsson, Professor

Role: PRINCIPAL_INVESTIGATOR

Division of Anesthesia, Skane University Hospital, Lund, Sweden

Locations

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Division of Brain, Heart and Lungs, Neurosurgical Clinic, Skane University Hospital, Lund

Lund, Skåne County, Sweden

Site Status

Countries

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Sweden

References

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Sturesson LW, Malmkvist G, Allvin S, Collryd M, Bodelsson M, Jonson B. An appropriate inspiratory flow pattern can enhance CO2 exchange, facilitating protective ventilation of healthy lungs. Br J Anaesth. 2016 Aug;117(2):243-9. doi: 10.1093/bja/aew194.

Reference Type DERIVED
PMID: 27440637 (View on PubMed)

Other Identifiers

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2012/381

Identifier Type: -

Identifier Source: org_study_id

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