Eecentric Exercise on Cardiopulmonary Fitness and Quality of Life With Chronic Obstructive Pulmonary Disease

NCT ID: NCT06869720

Last Updated: 2026-02-04

Basic Information

• Recruitment Status: WITHDRAWN
• Clinical Phase: NA
• Study Classification: INTERVENTIONAL
• Study Start Date: 2025-03-11
• Study Completion Date: 2025-07-31

Brief Summary

This study aims to investigate the effects of elliptical exercise on the six-minute walk test and quality of life in patients with chronic obstructive pulmonary disease (COPD) to identify the most efficient exercise training method.

Detailed Description

Background： Chronic respiratory diseases, including COPD, are leading causes of chronic illness and mortality worldwide. However, limitations in ventilation and muscle function restrict COPD patients from engaging in higher-power exercise therapies. Compared to concentric exercise, eccentric exercise can effectively improve health-related fitness and quality of life at lower cardiopulmonary and metabolic loads. Pulmonary rehabilitation programs have been shown to effectively improve symptoms of chronic respiratory diseases, increase exercise capacity, enhance quality of life, delay disease progression, prevent and treat acute exacerbations, and reduce mortality. Therefore, it is hoped that a "safe and effective" eccentric exercise strategy can be designed for COPD patients to comprehensively improve their cardiopulmonary/muscle fitness and quality of life, thereby improving the course of their disease.

Study Design： This is a one-year, single-center, prospective randomized controlled trial. Methods： This study plans to enroll 60 participants who will be randomly assigned to control and experimental groups. The intervention will take place in the pulmonary rehabilitation room on the sixth floor of Fu Jen Hospital. Each group will undergo a functional fitness test and complete a quality of life questionnaire before and after 24 sessions (over 12 weeks) of exercise training.

Effect： It is anticipated that after 24 sessions of elliptical exercise training, there will be an improvement in the functional fitness and in quality of life related to physical activity function.

Key words： Pulmonary rehabilitation; eccentric exercise; chronic obstructive pulmonary disease; cardiopulmonary fitness; functional fitness

Conditions

COPD (Chronic Obstructive Pulmonary Disease)

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: OTHER
• Blinding Strategy: NONE

Study Groups

Intervention Group: eccentric cycling exercise

Received eccentric cycling exercise

Group Type: EXPERIMENTAL

Eccentric bike

Intervention Type: DEVICE

Received eccentric cycling exercise

Control group

Undergoing conventional treatment

Group Type: ACTIVE_COMPARATOR

conventional group

Intervention Type: OTHER

Received conventional treatment

Interventions

Eccentric bike

Received eccentric cycling exercise

Intervention Type: DEVICE

conventional group

Received conventional treatment

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Having undergone pulmonary rehabilitation for more than 3 months
• Sign the written informed consent form
• FEV1/FVC < 0.70
• Approval for exercise training granted by a specialist physician's assessment
• Specialist physician's approval for exercise training

Exclusion Criteria

• Existing of tracheostomy
• Those who use oxygen therapy or ventilator at home
• Severe heart failure (NYHA III-IV)
• Neuromuscular disease
• Acute exacerbation within the past three months
• Those who are unable to cooperate with the cardiopulmonary exercise test

• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Fu Jen Catholic University

OTHER

Sponsor Role: lead

Responsible Party

Ke-Yun, Chao

Assistant Professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Ke-Yun Chao, PhD

Role: PRINCIPAL_INVESTIGATOR

Fu Jen Catholic University

Locations

Fu Jen Catholic University Hospital, Fu Jen Catholic University

New Taipei City, , Taiwan

Countries

Taiwan

Other Identifiers

FJUH113384

Identifier Type: -

Identifier Source: org_study_id