Mechanical Ventilation in the Emergency Department: A Prospective Cross-Sectional Study

NCT ID: NCT01628523

Last Updated: 2020-03-23

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

View full results

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Total Enrollment

219 participants

Study Classification

OBSERVATIONAL

Study Start Date

2012-07-31

Study Completion Date

2014-03-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Despite its life-saving potential, the mechanical ventilator has great potential to do harm. Despite years of research, the mortality in acute lung injury (ALI) remains very high. Treatment options after ALI onset are very limited, therefore prevention may be the best option. Unfortunately, the emergency department has not been studied with respect to mechanical ventilation practices, and its contribution to ALI is unknown. The investigators hypothesize that mechanical ventilation is frequently used in the ED and for a variety of reasons, and that ED mechanical ventilation has an effect on long term outcomes.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Respiratory Failure Mechanical Ventilation Acute Lung Injury

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

OTHER

Study Time Perspective

PROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

All ED patients requiring mechanical ventilation

For inclusion in the study, patients will have to require mechanical ventilation either via an endotracheal tube or tracheostomy tube.

Intervention Type OTHER

Mechanical ventilation via an endotracheal tube or tracheostomy tube

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

For inclusion in the study, patients will have to require mechanical ventilation either via an endotracheal tube or tracheostomy tube.

Mechanical ventilation via an endotracheal tube or tracheostomy tube

Intervention Type OTHER

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Ventilation either via an endotracheal tube or tracheostomy

Exclusion Criteria

* Non-invasive positive pressure ventilation;
* Death in the immediate post-intubation phase of care;
* Chronic ventilator-dependence, either at home or extended care facility.
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

University of Iowa

OTHER

Sponsor Role collaborator

Christiana Care Health Services

OTHER

Sponsor Role collaborator

University of Cincinnati

OTHER

Sponsor Role collaborator

Washington University School of Medicine

OTHER

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Responsibility Role SPONSOR

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

Brian M Fuller, MD

Role: PRINCIPAL_INVESTIGATOR

Washington University School of Medicine in St. Louis

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Christiana Care Health System

Newark, Delaware, United States

Site Status

University of Iowa College of Medicine

Iowa City, Iowa, United States

Site Status

Washington University School of Medicine

St Louis, Missouri, United States

Site Status

University of Cincinnati College of Medicine

Cincinnati, Ohio, United States

Site Status

Countries

Review the countries where the study has at least one active or historical site.

United States

References

Explore related publications, articles, or registry entries linked to this study.

Fuller BM, Mohr NM, Miller CN, Deitchman AR, Levine BJ, Castagno N, Hassebroek EC, Dhedhi A, Scott-Wittenborn N, Grace E, Lehew C, Kollef MH. Mechanical Ventilation and ARDS in the ED: A Multicenter, Observational, Prospective, Cross-sectional Study. Chest. 2015 Aug;148(2):365-374. doi: 10.1378/chest.14-2476.

Reference Type DERIVED
PMID: 25742126 (View on PubMed)

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

201205165

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.

Intubated ICU Patients
NCT02171091 TERMINATED