Mechanical Ventilation and Respiratory Muscle Work of Breathing in Acute Respiratory Distress Syndrome (ARDS) Patients
NCT ID: NCT01289600
Last Updated: 2015-06-10
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
12 participants
INTERVENTIONAL
2011-01-31
2013-03-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
CROSSOVER
TREATMENT
NONE
Study Groups
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Pressure support ventilation, ARDSnet
Mechanical ventilator is set to pressure support ventilation (6 ml/kg) for 30 min with positive end expiratory pressure (PEEP) set according to the "higher arm" of the ARDS network consensus.
Mechanical ventilation
The mechanical ventilator is set to different ventilation modes as described in the individual arms.
Pressure control ventilation, ARDSnet
Mechanical ventilator is set to pressure control ventilation (6 ml/kg) for 30 min with PEEP set according to the "higher arm" of the ARDS network consensus.
Mechanical ventilation
The mechanical ventilator is set to different ventilation modes as described in the individual arms.
Neurally adjusted ventilatory assist, ARDSnet
Mechanical ventilator is set to NAVA for 30 min with PEEP set according to the "higher arm" of the ARDS network consensus.
Mechanical ventilation
The mechanical ventilator is set to different ventilation modes as described in the individual arms.
Neurally adjusted ventilatory assist, titrated
Mechanical ventilator is set to NAVA for 30 min with PEEP titrated using the diaphragm EMG signal.
Mechanical ventilation
The mechanical ventilator is set to different ventilation modes as described in the individual arms.
Interventions
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Mechanical ventilation
The mechanical ventilator is set to different ventilation modes as described in the individual arms.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* meeting criteria for ARDS
* mean arterial blood pressure \> 65 mmHg (with or w/o vasopressors)
Exclusion Criteria
* increased intracranial pressure
* contra-indication naso-gastric tube
* diagnosed neuro-muscular disorder
* recent (\<12 hours) use of muscle relaxants
* exclusion from sedation interruption protocol as used in our institution
* open chest or- abdomen
* very high inspiratory flow rate during supported ventilation
* inability to obtain informed consent
18 Years
ALL
No
Sponsors
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University Medical Center Nijmegen
OTHER
Responsible Party
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Leo Heunks
MD PhD
Principal Investigators
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Leo Heunks, MD, PhD
Role: PRINCIPAL_INVESTIGATOR
Radboud University Nijmegen Medical Center
Locations
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University Medical Center Nijmegen
Nijmegen, Gelderland, Netherlands
Countries
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Other Identifiers
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ARDS1
Identifier Type: -
Identifier Source: org_study_id
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