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The Predictive Effect of the Inflammatory Response on the Evacuation of Mechanical Ventilation and the Mechanism

NCT ID: NCT02820090

Last Updated: 2016-06-30

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

300 participants

Study Classification

OBSERVATIONAL

Study Start Date

2014-05-31

Study Completion Date

2017-04-30

Brief Summary

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Infection and trauma take a important role in the acute respiratory failure.There are different causes and degrees of inflammatory reaction in the critically ill patient. The inflammatory reaction should also affect patients on mechanical ventilation dependence with body physiological response and disease prognosis in patients. Therefore, the investigators hypothesize that inflammation may have an important role in the prediction of weaning from mechanical ventilation.

Detailed Description

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In the process of mechanical ventilation, the patients were divided into two groups according to the failure of spontaneous breathing test and spontaneous breathing test.In the index of predicting mechanical ventilation, the investigators will take the index of inflammatory response, the function index of diaphragm and the amount of exhaled CO2 into account to reduce the failure rate of mechanical ventilation.

Conditions

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Systemic Inflammatory Response Syndrome Ventilator Weaning

Keywords

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Inflammatory Factor Mechanical Ventilation

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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Success with SBT

The patient have a success in SBT.

No interventions assigned to this group

Success with mechanical ventilation

Weaning from mechanical ventilation is successful

No interventions assigned to this group

failure with SBT

The patient have a failure in SBT.

No interventions assigned to this group

failure with mechanical ventilation

Weaning from mechanical ventilation is failed

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* oral, nasal tracheal intubation and mechanical ventilation in patients with respiratory failure
* mechanical ventilation time over than 48 hours
* Glasgow score greater more than or equal to 13 points

Exclusion Criteria

* Aged less than 14 years or more than 80 years old
* patients with neuromuscular disease
* pure heart failure pulmonary edema patients
* patients with tracheotomy
Minimum Eligible Age

14 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Beijing Chao Yang Hospital

OTHER

Sponsor Role lead

Responsible Party

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Yingmin Ma

Vice President of the Beijing Chao Yang Hospital

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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MA yingmin, professor

Role: STUDY_DIRECTOR

Beijing Chao Yang Hospital

Other Identifiers

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15210511726

Identifier Type: -

Identifier Source: org_study_id