Ventilator Strategies in ICU Patients With COVID-19 - a National-wide Retrospective Observational Study.

NCT ID: NCT05102630

Last Updated: 2021-11-11

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

1193 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-06-01

Study Completion Date

2022-04-30

Brief Summary

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Mechanical ventilation is likely lifesaving in patients with coronavirus disease 2019 (COVID-19) but may also result in adverse events. Only few studies describe the strategies used and adverse effect of mechanical ventilation in an unselected population of ICU patients with COVID-19.

This study is designed to be a retrospective study focusing on all mechanical ventilated ICU patients with COVID-19 included in the national Danish COVID ICU database between 10.03.2020 - 02.04.2021 i.e. a total of 1,193 patients. The investigators will register the use of the core interventions around mechanical ventilation and its potential adverse event, including barotrauma and prolonged ventilation.

This study will provide important data on the ventilation strategies used and its potential adverse events in unselected ICU patients with COVID-19 and thereby inform clinicians, patients, policy-makers, and future research in this area.

Detailed Description

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Conditions

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ARDS Due to COVID-19

Keywords

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ARDS Mechanical Ventilation COVID-19

Study Design

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Observational Model Type

COHORT

Study Time Perspective

OTHER

Eligibility Criteria

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Inclusion Criteria

All mechanical ventilated patients registered in the national Danish COVID ICU database between 10.03.2020 - 02.04.2021 i.e.

1. Admitted to an ICU in Denmark
2. Laboratory-confirmed SARS-CoV-2 infection
3. Use of invasive mechanical ventilation (ventilation via a cuffed endotracheal tube) at any time during the ICU stay

Exclusion Criteria

None
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Odense University Hospital

OTHER

Sponsor Role collaborator

Aalborg University Hospital

OTHER

Sponsor Role collaborator

Bispebjerg Hospital

OTHER

Sponsor Role collaborator

Herlev and Gentofte Hospital

OTHER

Sponsor Role collaborator

Hvidovre University Hospital

OTHER

Sponsor Role collaborator

Rigshospitalet, Denmark

OTHER

Sponsor Role collaborator

Aarhus University Hospital

OTHER

Sponsor Role collaborator

Region Zealand

OTHER

Sponsor Role collaborator

University of Southern Denmark

OTHER

Sponsor Role lead

Responsible Party

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Anne Craveiro Brøchner

Ph D, associate professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Anne C Brøchner, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

University of Southern Denmark

Locations

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Department of Anaesthesiology and Intensive Care Medicine, Aalborg University Hospital

Aalborg, , Denmark

Site Status RECRUITING

Department of Anesthesiology and Intensive Care, Kolding Hospital

Kolding, , Denmark

Site Status RECRUITING

Countries

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Denmark

Central Contacts

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Anne C Brøchner, MD, Ph D

Role: CONTACT

Phone: +4529464468

Email: [email protected]

Nikolai arnold-larsen, MD

Role: CONTACT

Email: [email protected]

Facility Contacts

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Frederik Nielsen, MD

Role: primary

Anne C Brøchner, MD, Ph D

Role: primary

Other Identifiers

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2020-C 19-29-10-21

Identifier Type: -

Identifier Source: org_study_id