Correlation Between 3 Phase Bone Scintigraphy and Pressure Pain Thresholds in Patients With Complex Regional Pain Syndrome (CRPS)

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

53 participants

Study Classification

OBSERVATIONAL

Study Start Date

2010-10-31

Study Completion Date

2011-10-31

Brief Summary

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The aim of the study is to investigate the correlation between increased bone metabolism in the 3 phase bone scintigraphy (TPBS) and decreased pressure pain thresholds in patients with complex regional pain syndrome (CRPS) of the upper limb and a non-CRPS-group. The investigators assume that there will be a significant correlation between the investigated values in the CRPS-group whereas the non-CRPS-group shows no significant correlation.

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Detailed Description

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Pressure pain of the distal hand joints is a predominant symptom of CRPS. But so far, the diagnostic value of pressure pain in the diagnosis of CRPS has not been investigated. We compared the pressure pain thresholds of the carpus, metacarpophalangeal and proximal interphalangeal joints to a region of interest-based (ROI) analysis of a TBPS in patients with CRPS and patients with limb pain of other origin (non-CRPS-group).Additionally, the PPTs were established for a healthy control group to get reference data.

Conditions

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Complex Regional Pain Syndrome Type I of the Upper Limb Unilateral Limb Pain of Other Origin Healthy Subjects

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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Patients with CRPS

18 patients with unilateral CPRS of the upper limb were included to the study

Pressure Pain measurement

Intervention Type PROCEDURE

The pressure pain thresholds were established using a manual pressure algometer. The investigated joints were the carpus, the metacarpophalangeal and the proximal interphalangeal joints

Patients with limb pain of other origin

17 patients with unilateral upper limb pain of other origin served as control group

Pressure Pain measurement

Intervention Type PROCEDURE

The pressure pain thresholds were established using a manual pressure algometer. The investigated joints were the carpus, the metacarpophalangeal and the proximal interphalangeal joints

Healthy subjects

18 healthy subjects were included to establish reference data for the pressure pain thresholds

Pressure Pain measurement

Intervention Type PROCEDURE

The pressure pain thresholds were established using a manual pressure algometer. The investigated joints were the carpus, the metacarpophalangeal and the proximal interphalangeal joints

Interventions

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Pressure Pain measurement

The pressure pain thresholds were established using a manual pressure algometer. The investigated joints were the carpus, the metacarpophalangeal and the proximal interphalangeal joints

Intervention Type PROCEDURE

Other Intervention Names

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SOMEDIC Production AB, Sweden, Algometer Type II

Eligibility Criteria

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Inclusion Criteria

every participant:

* aged \> 18 years with written informed consent
* adequate understanding of the german language
* indication for a TPBS independent of the study

Patients with CRPS:

* patients with CRPS type 1 of the upper limb diagnosed on the basis of the budapest criteria (Harden, Bruehl et al., 2010)
* unilateral pain

Control group:

* patients with pain of the upper limbs of other origin than CRPS who underwent a TPBS
* unilateral pain

Healthy subjects:

* checked by the DFNS IMI questionnaire

Exclusion Criteria

* missing informed consent
* inadequate understanding of the german language
* disease duration of more than 12 months
* other disease of the upper extremity (e.g. polyarthrosis, rheumatoid arthritis)
* pregnancy/ lactation period

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes