The Association Between Conditioned Pain Modulation and Pain Catastrophizing in Chronic Low Back Pain
NCT ID: NCT03644810
Last Updated: 2018-12-24
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
44 participants
INTERVENTIONAL
2017-05-01
2018-11-08
Brief Summary
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Detailed Description
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Studies utilizing functional magnetic resonance imaging (fMRI) have demonstrated that the supraspinal areas involved in pain-related cognitive processing to a great extent overlap with those involved in endogenous pain modulation. Therefore, it is plausible that factors such as pain catastrophizing thoughts may affect the nervous systems ability to dampen pain.
Chronic low back pain is the single clinical problem with the biggest impact in the modern society. Previous studies have demonstrated that pain catastrophizing and reduced endogenous pain inhibition are part of the clinical picture. However, previous studies have never investigated a potential relationship between these two factors.
Conditions
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Study Design
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NON_RANDOMIZED
PARALLEL
DIAGNOSTIC
SINGLE
Study Groups
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Chronic low back pain
Individuals with chronic low back pain. Baseline assessment of pain intensity, function, pain duration and pain catastrophizing thoughts is performed
Pain sensitivity at the back and lower leg is measured at baseline and immediately after performing the cold pressor test
PPT measurement
The sensitivity to pressure which is gradually increased is assessed. The procedure is performed at the back and the lower leg
Pain catastrophizing scale
A validated questionnaire that measures three domains of pain-related catastrophizing thoughts: helplessness, rumination and excessive magnification
Cold Pressor Test
The participant submerges one hand into a tank of cold (5 deg C), circulating water. The procedure is commonly know to decrease the sensitivity to pressure (PPT procedure) so that a difference appears in pain sensitivity when comparing PPT values before and after the procedure
Healthy controls
Healthy, pain-free individuals who are age and gender matched to the low back pain group fill out the pain catastrophizing scale
Pain sensitivity at the back and lower leg is measured at baseline and immediately after performing the cold pressor test
PPT measurement
The sensitivity to pressure which is gradually increased is assessed. The procedure is performed at the back and the lower leg
Pain catastrophizing scale
A validated questionnaire that measures three domains of pain-related catastrophizing thoughts: helplessness, rumination and excessive magnification
Cold Pressor Test
The participant submerges one hand into a tank of cold (5 deg C), circulating water. The procedure is commonly know to decrease the sensitivity to pressure (PPT procedure) so that a difference appears in pain sensitivity when comparing PPT values before and after the procedure
Interventions
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PPT measurement
The sensitivity to pressure which is gradually increased is assessed. The procedure is performed at the back and the lower leg
Pain catastrophizing scale
A validated questionnaire that measures three domains of pain-related catastrophizing thoughts: helplessness, rumination and excessive magnification
Cold Pressor Test
The participant submerges one hand into a tank of cold (5 deg C), circulating water. The procedure is commonly know to decrease the sensitivity to pressure (PPT procedure) so that a difference appears in pain sensitivity when comparing PPT values before and after the procedure
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* chronic low back pain ( lasting more than 3 months)
* intensity of ≥ 3/10 on a numeric rating scale
* pain is located in the area between the gluteal folds below to the thoracolumbal junction above.
Controls:
No current or previous history of musculoskeletal pain of ongoing nature
Exclusion Criteria
* Signs of radicular pain or other specific medical conditions e.g. rheumatologic disease or diabetes
* Pregnancy
18 Years
60 Years
ALL
Yes
Sponsors
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Spine Centre of Southern Denmark
OTHER
Aalborg University
OTHER
Responsible Party
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Thorvaldur Skuli Palsson
Principal Investigator
Principal Investigators
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Thorvaldur S Palsson, PhD
Role: PRINCIPAL_INVESTIGATOR
Aalborg University
Locations
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Spine Centre of Southern Denmark
Middelfart, Southern Denmark, Denmark
Countries
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References
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Edwards RR, Smith MT, Stonerock G, Haythornthwaite JA. Pain-related catastrophizing in healthy women is associated with greater temporal summation of and reduced habituation to thermal pain. Clin J Pain. 2006 Oct;22(8):730-7. doi: 10.1097/01.ajp.0000210914.72794.bc.
Vaegter HB, Palsson TS, Graven-Nielsen T. Facilitated Pronociceptive Pain Mechanisms in Radiating Back Pain Compared With Localized Back Pain. J Pain. 2017 Aug;18(8):973-983. doi: 10.1016/j.jpain.2017.03.002. Epub 2017 Mar 24.
Meints SM, Wang V, Edwards RR. Sex and Race Differences in Pain Sensitization among Patients with Chronic Low Back Pain. J Pain. 2018 Dec;19(12):1461-1470. doi: 10.1016/j.jpain.2018.07.001. Epub 2018 Jul 17.
Mlekusch S, Neziri AY, Limacher A, Juni P, Arendt-Nielsen L, Curatolo M. Conditioned Pain Modulation in Patients With Acute and Chronic Low Back Pain. Clin J Pain. 2016 Feb;32(2):116-21. doi: 10.1097/AJP.0000000000000238.
Correa JB, Costa LO, de Oliveira NT, Sluka KA, Liebano RE. Central sensitization and changes in conditioned pain modulation in people with chronic nonspecific low back pain: a case-control study. Exp Brain Res. 2015 Aug;233(8):2391-9. doi: 10.1007/s00221-015-4309-6. Epub 2015 May 12.
Other Identifiers
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S-20170021
Identifier Type: -
Identifier Source: org_study_id