The EVICEL® Gastrointestinal Study

NCT ID: NCT01589822

Last Updated: 2015-02-25

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2

Total Enrollment

214 participants

Study Classification

INTERVENTIONAL

Study Start Date

2012-06-30

Study Completion Date

2014-09-30

Brief Summary

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The purpose of this study is to evaluate the safety and effectiveness of EVICEL® Fibrin Sealant (Human) for use as an adjunct to gastrointestinal (GI) surgery.

Detailed Description

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This is a single blind, randomized, multi-center controlled study evaluating the safety and effectiveness of EVICEL® when used as an adjunct to gastrointestinal (GI) surgery.

Conditions

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Gastrointestinal Diseases

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Participants

Study Groups

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EVICEL Fibrin Sealant: Randomized

EVICEL is a human plasma-derived fibrin sealant composed of two components - thrombin and fibrinogen.

Group Type EXPERIMENTAL

EVICEL Fibrin Sealant

Intervention Type BIOLOGICAL

Intraoperative

Standard of Care

Standard surgical technique for GI anastomosis.

Group Type NO_INTERVENTION

No interventions assigned to this group

Experimental: EVICEL Fibrin Sealant: Non-Randomized

EVICEL is a human plasma-derived fibrin sealant composed of two components - thrombin and fibrinogen

Group Type EXPERIMENTAL

EVICEL Fibrin Sealant

Intervention Type BIOLOGICAL

Intraoperative

Interventions

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EVICEL Fibrin Sealant

Intraoperative

Intervention Type BIOLOGICAL

Other Intervention Names

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Fibrin sealant

Eligibility Criteria

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Inclusion Criteria

* Subjects undergoing primary elective GI surgery
* Subjects ≥ 18 years of age who are willing to participate in the study and provide written informed consent prior to any study-related procedures

Exclusion Criteria

* Avastin use within 30 days prior to surgery;
* Known hypersensitivity to the human blood products or the components of the investigational product;
* Female subjects who are pregnant or nursing;
* Exposure to another investigational drug or device in a clinical trial within 30 days prior to surgery or planned/intended for the 90 day follow up period after surgery.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Ethicon, Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Richard Kocharian, MD

Role: STUDY_DIRECTOR

Ethicon, Inc.

Locations

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Clinical Investigation Site #1

Irvine, California, United States

Site Status

Clinical Investigation Site #2

Jacksonville, Florida, United States

Site Status

Clinical Investigation Site #5

Augusta, Georgia, United States

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Clinical Investigation Site #4

New Orleans, Louisiana, United States

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Clinical Investigation Site #8

Portland, Oregon, United States

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Clinical Investigation Site #23

Greenville, South Carolina, United States

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Clinical Investigation Site #3

Houston, Texas, United States

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Clinical Investigation Site #6

Houston, Texas, United States

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Clinical Investigation Site #19

New Lambton, New South Wales, Australia

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Clinical Investigation Site #18

South Adelaide, , Australia

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Clinical Investigation Site #17

Genk, , Belgium

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Clinical Investigation Site #16

Ghent, , Belgium

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Clinical Investigation Site #10

Vancouver, British Columbia, Canada

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Clinical Investigation Site #9

Toronto, Ontario, Canada

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Clinical Investigation Site #20

Auckland, , New Zealand

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Clinical Investigation Site #22

Seoul, , South Korea

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Clinical Investigation Site #21

Seoul, , South Korea

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Clinical Investigation Site #15

Edinburgh, , United Kingdom

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Clinical Investigation Site #11

Leicester, , United Kingdom

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Clinical Investigation Site #12

Nottingham, , United Kingdom

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Clinical Investigation Site #13

Plymouth, , United Kingdom

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Clinical Investigation Site #14

Sheffield, , United Kingdom

Site Status

Countries

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United States Australia Belgium Canada New Zealand South Korea United Kingdom

Other Identifiers

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400-11-002

Identifier Type: -

Identifier Source: org_study_id

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