The Effects of Polyphenol-rich Berry Juice on Blood Pressure in Hypertensive Subjects
NCT ID: NCT01568983
Last Updated: 2012-07-03
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
PHASE3
153 participants
INTERVENTIONAL
2011-12-31
2012-06-30
Brief Summary
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The study is a 12 week double blinded randomized controlled intervention trial. The subjects will be divided in three groups where one receives a placebo juice while the two other will consume 0.5 liter of juice containing different levels of polyphenols. Blood pressure will be monitored and blood samples will be taken.
Detailed Description
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Conditions
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Study Design
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RANDOMIZED
FACTORIAL
PREVENTION
QUADRUPLE
Study Groups
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Control
12 weeks intake of 0.5 liter/day placebo juice containing sugar, aromas and salt corresponding to the berry juices in the other groups.
Blood pressure will be taken at time point 0,6 and 12 weeks. Blood and urine samples will be collected and weight and bioelectric impedance will be monitored at time point 0 and 12 weeks.
Placebo
500 ml/day Per 100g 6.25 g sucrose 6.25 g maltodextrin 1.3 g citric acid E330 (pH 3.0) 2.5 g Carmine solution E120 (4% carmine colouring agent) 0.025 g blueberry aroma Potassium sorbate E202 water
Mana-juice
12 weeks intake of 0.5 liter/day of a commercially available berry juice (Mana blue) rich in polyphenols (grape, cherries, bilberries and aronia).
Blood pressure will be taken at time point 0,6 and 12 weeks. Blood and urine samples will be collected and weight and bioelectric impedance will be monitored at time point 0 and 12 weeks.
Mana-juice
500 ml/day of a grape,cherry, bilberry,aronia juice 13g carbohydrates/100g 150mg K/100g
Optijuice
12 weeks intake of 0.5 liter/day of berry juice rich in polyphenols (grape, cherries, blueberry and aronia) and added extract from press cake of black currant.
Blood pressure will be taken at time point 0,6 and 12 weeks. Blood and urine samples will be collected and weight and bioelectric impedance will be monitored at time point 0 and 12 weeks.
Optijuice
500 ml/day of a Grape,cherry, bilberry,aronia, black current juice 13g carbohydrates/100g 150mg K/100g
Interventions
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Placebo
500 ml/day Per 100g 6.25 g sucrose 6.25 g maltodextrin 1.3 g citric acid E330 (pH 3.0) 2.5 g Carmine solution E120 (4% carmine colouring agent) 0.025 g blueberry aroma Potassium sorbate E202 water
Mana-juice
500 ml/day of a grape,cherry, bilberry,aronia juice 13g carbohydrates/100g 150mg K/100g
Optijuice
500 ml/day of a Grape,cherry, bilberry,aronia, black current juice 13g carbohydrates/100g 150mg K/100g
Eligibility Criteria
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Inclusion Criteria
* BMI 20-35 kg/m2
* Stable weight (change \<4 kg previous 12 weeks)
Exclusion Criteria
* Diabetes type I or II
* Smokers
* Allergy to grape, cherries, blueberries/bilberries, black currant, aronia
* Supplements for weight loss
* Changes in pharmacological treatment of hyperlipidemia or hyperglycemia (initiation, termination or changes in dosage) last 30 days prior to inclusion or during the study period (run-in and intervention)
* Participation in a drug trial during the previous 30 days
50 Years
70 Years
ALL
Yes
Sponsors
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Fellesjuice AS
UNKNOWN
Nofima
OTHER
University of Oslo
OTHER
Responsible Party
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Rune Blomhoff
Professor
Principal Investigators
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Rune Blomhoff, PhD
Role: PRINCIPAL_INVESTIGATOR
University of Oslo
Locations
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University of Oslo
Oslo, , Norway
Countries
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Other Identifiers
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Optijuice
Identifier Type: -
Identifier Source: org_study_id