The Effect of Kiwi on Blood Pressure, Endothelial Function, Antioxidant Capacity and Gene Expression

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

118 participants

Study Classification

INTERVENTIONAL

Study Start Date

2009-08-31

Study Completion Date

2010-12-31

Brief Summary

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The purpose of this study is to determine whether the intake of kiwi fruits will reduce systolic and diastolic blood pressure compared to intake of apples. The investigators hypothesize that the increased intake lutein or other components in the kiwi fruit will enhance nitric oxide bioavailability and lead to vascular relaxation.

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Detailed Description

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An interesting finding in the Oslo Antioxidant Study was that intake of 3 kiwi fruits reduced blood pressure in a clinical significant manner compared to controls. The mechanism for the blood pressure reducing effect of kiwi or the responsible components are not elucidated. However, plasma lutein levels and antioxidant capacity measured by the ferric reducing antioxidant power was increased in the kiwi group. Moreover, gene expression was also altered by the increased intake of kiwi.

Conditions

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Hypertension

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Outcome Assessors

Study Groups

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Kiwi fruits

Group Type ACTIVE_COMPARATOR

Kiwi fruits

Intervention Type OTHER

Daily intake of 3 kiwi fruits for 8 weeks

Apple

Group Type PLACEBO_COMPARATOR

Apple

Intervention Type OTHER

Daily intake of 1 apple (equivalent in energy) for 8 weeks

Interventions

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Kiwi fruits

Daily intake of 3 kiwi fruits for 8 weeks

Intervention Type OTHER

Apple

Daily intake of 1 apple (equivalent in energy) for 8 weeks

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Systolic blood pressure 130-159 mmHg
* Diastolic blood pressure 85-99 mmHg
* Body mass index \<35 kg/m2

Exclusion Criteria

* Systolic blood pressure \>160 mmHg or \<129 mmHg
* Diastolic blood pressure \>100 mmHg or \<84 mmHg
* Current use or need for blood pressure lowering medication
* Symptomatic cardiovascular disease, diabetes, renal dysfunction, psychiatric disorder, pregnancy or lactation, history of obesity surgery.

Minimum Eligible Age

35 Years

Maximum Eligible Age

69 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes