Event Related Potentials in Borderline Personality Disorder and Major Depression

NCT ID: NCT01469663

Last Updated: 2021-05-18

Basic Information

• Recruitment Status: TERMINATED
• Total Enrollment: 30 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2011-07-31
• Study Completion Date: 2015-03-31

Brief Summary

This study examines whether depression in people with borderline personality disorder is different than depression in people without borderline personality disorder.

Unlike people who have depression alone (i.e. without borderline personality disorder), people with borderline personality disorder have depressions that often do not improve with medications. This makes treating depression much more challenging in someone with borderline personality disorder than without borderline personality disorder.

Borderline personality disorderis associated with difficulty in understanding and communicating feelings. Impaired emotion processing may reflect dysfunction of an area of the brain, the anterior cingulate.

Depression is associated with changes in anterior cingulate activity. The investigators believe that when borderline personality disorder is present with depression, brain activity changes in the anterior cingulate will not be the same as in depressed patients without borderline personality disorder.

An electroencephalogram records brain electrical activity. In this study, the investigators will measure electroencephalogram indices reflecting anterior cingulate activity.

HYPOTHESIS: In this study, the investigators predict that when borderline personality is present with depression, electroencephalogram indices of anterior cingulate activity will be different from when depression is present alone (without borderline personality). This could help to explain why people with borderline personality have depressions that are harder to treat than depressions in people without borderline personality.

The investigators also predict that electroencephalogram indices of the anterior cingulate will reflect emotional processing ability, as measured by validated questionnaires.

Conditions

Borderline Personality Disorder; Major Depression

Study Design

• Observational Model Type: OTHER
• Study Time Perspective: CROSS_SECTIONAL

Study Groups

Healthy Control

Healthy participants without borderline personality or depression

No interventions assigned to this group

Major Depression, No Borderline Personality Disorder

With major depression and no borderline personality

No interventions assigned to this group

Major Depression + Borderline Personality Disorder

With major depression and borderline personality disorder

No interventions assigned to this group

No Major Depression, Borderline Personality Disorder

With no major depression, but with borderline personality disorder

No interventions assigned to this group

Eligibility Criteria

Inclusion Criteria

• age between 18 and 45
• female
• noncontrols diagnosis: major depression &/or borderline personality disorder
• Control participants should have neither major depression or borderline pers.
• meet Structured Controlled Interview for DSM - II cut off scores
• meet Beck Depression Inventory (BDI)cut off scores
• meet Borderline Evaluation of Severity Over Time(BEST) cut off scores.

Exclusion Criteria

• based on having none of the below diagnoses from patient history, prior clinical records and based on MINI Plus International Neuropsychiatry Interview
• schizophrenia
• psychosis
• Attention Deficit Hyperactivity Disorder
• Obsessive Compulsive Disorder
• bipolar disorder
• mental retardation
• dementia
• CNS disease
• Post-Traumatic Stress Disorder in non-borderline personality disorder groups
• Recreational drug or alcohol use in the past week.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 45 Years
• Eligible Sex: FEMALE
• Accepts Healthy Volunteers: Yes

Sponsors

Syracuse University

OTHER

Sponsor Role: collaborator

State University of New York - Upstate Medical University

OTHER

Sponsor Role: lead

Responsible Party

Amruther G Ramamurthy

Assistant Professor, Dept of Psychiatry

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Amruthur Ramamurthy, MD

Role: PRINCIPAL_INVESTIGATOR

State University of New York - Upstate Medical University

Locations

Syracuse University - CNY Medical Center

Syracuse, New York, United States

Upstate Medical University

Syracuse, New York, United States

Countries

United States

Other Identifiers

5910

Identifier Type: -

Identifier Source: org_study_id