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Generation of Haploid Stem Cells From Human Germ Cells

NCT ID: NCT01454765

Last Updated: 2013-12-11

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

10 participants

Study Classification

OBSERVATIONAL

Study Start Date

2011-12-31

Study Completion Date

2015-08-31

Brief Summary

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Human cells are diploid (contain a double set of chromosomes). The diploid genome is complex and therefore limits genetic research approaches in biomedical models. To overcome this problem experimental generation of haploid stem cells has been done in animals. The investigators aim at generating haploid stem cells from human germ cells that are a useful tool in genetic research and screening.

Detailed Description

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Human cells are diploid (contain a double set of chromosomes). The diploid genome is complex and therefore limits genetic research approaches in biomedical models. To overcome this problem experimental generation of haploid stem cells has been done in animal models. haploid cells are easier for genetic manipulations, such as knock-in and knock-out of genes, and therefore should make a better experimental model. The investigators aim at generating haploid stem cells from human haploid germ cells.

Conditions

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Induced Pluripotent Stem Cells

Study Design

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Study Time Perspective

PROSPECTIVE

Study Groups

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Sperm sample from healthy volunteers

generation of stem cells

Intervention Type OTHER

Collected germ cells will be cultured in medium. The germ cell cultures will be infected with reprograming factors. Rare colonies with characteristic stem cell morphologies will be expanded.

Interventions

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generation of stem cells

Collected germ cells will be cultured in medium. The germ cell cultures will be infected with reprograming factors. Rare colonies with characteristic stem cell morphologies will be expanded.

Intervention Type OTHER

Other Intervention Names

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generation of stem cells from somatic haploid germ cells

Eligibility Criteria

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Inclusion Criteria

1. males over the age of 18 and under 50
2. no known chronic illness
3. not taking any chronic drugs

Exclusion Criteria

1. females
2. males under 18 or over 50
3. any known chronic illness
4. taking chronic medications
Minimum Eligible Age

18 Years

Maximum Eligible Age

50 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes

Sponsors

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Rambam Health Care Campus

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Itay Maza, M.D

Role: PRINCIPAL_INVESTIGATOR

Rambam Health Care Campus

Locations

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Rambam medical center

Haifa, , Israel

Site Status NOT_YET_RECRUITING

Weizmann institute of science

Rehovot, , Israel

Site Status RECRUITING

Countries

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Israel

Facility Contacts

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Itay Maza, MD

Role: primary

Itay Maza, MD

Role: primary

Other Identifiers

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rmb-maza0001-ctil

Identifier Type: -

Identifier Source: org_study_id