Dynamic Myocardial Perfusion Imaging by 320 Multidetector Computed Tomography

NCT ID: NCT01368237

Last Updated: 2018-06-25

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

51 participants

Study Classification

OBSERVATIONAL

Study Start Date

2006-05-31

Study Completion Date

2017-01-01

Brief Summary

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Recent advances in technology have resulted in the development of scanners that can image the heart blood vessels within 10 to 20 minutes but without the need for admission to hospital or insertion of catheters. Further advances in technology allow the visualisation of both the blood vessels and the supply of blood to the heart muscle. Here we propose to assess the latest and most powerful computed tomography scanner and compare it to magnetic resonance and conventional coronary angiography.

Detailed Description

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Conditions

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Coronary Heart Disease

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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Patients

Patients awaiting invasive coronary angiography

Computed tomography scan

Intervention Type RADIATION

Computed tomography will be performed using a 320 multidetector computed tomography scanner and may include coronary calcium score, coronary angiography and imaging of myocardial perfusion, function and viability.

Interventions

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Computed tomography scan

Computed tomography will be performed using a 320 multidetector computed tomography scanner and may include coronary calcium score, coronary angiography and imaging of myocardial perfusion, function and viability.

Intervention Type RADIATION

Eligibility Criteria

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Inclusion Criteria

* referred for invasive coronary angiography because of suspected coronary heart disease

Exclusion Criteria

* inability or unwillingness to undergo computed tomography or magnetic resonance imaging
* renal failure (serum creatinine \>200 micromol/L or estimated glomerular filtration rate \<30 mL/min)
* hepatic failure
* allergy to iodinated contrast or gadolinium
* pregnancy
* contraindication to adenosine infusion
* inability to give informed consent
* inability to perform fractional flow reserve during invasive coronary angiography
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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NHS Lothian

OTHER_GOV

Sponsor Role collaborator

University of Edinburgh

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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David E Newby

Role: PRINCIPAL_INVESTIGATOR

University of Edinburgh

Locations

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Royal Infirmary of Edinburgh

Edinburgh, Scotland, United Kingdom

Site Status

Countries

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United Kingdom

References

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Papanastasiou G, Williams MC, Dweck MR, Alam S, Cooper A, Mirsadraee S, Newby DE, Semple SI. Quantitative assessment of myocardial blood flow in coronary artery disease by cardiovascular magnetic resonance: comparison of Fermi and distributed parameter modeling against invasive methods. J Cardiovasc Magn Reson. 2016 Sep 13;18(1):57. doi: 10.1186/s12968-016-0270-1.

Reference Type DERIVED
PMID: 27624746 (View on PubMed)

Other Identifiers

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210/R/CAR/11

Identifier Type: -

Identifier Source: org_study_id

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