Effects of Intranasal Oxytocin and Vasopressin on Social Behavior

NCT ID: NCT01296269

Last Updated: 2011-04-08

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

150 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-04-30

Brief Summary

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The purpose of this study is to investigate the role of a one-time intranasal administration of the oxytocin, vasopressin, or placebo on prosocial decision making such as cooperation and altruism in a healthy population of student controls.

Detailed Description

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Conditions

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Healthy

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

DOUBLE

Participants Caregivers

Study Groups

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Vasopressin

vasopressin condition

Group Type EXPERIMENTAL

Arginine Vasopressin

Intervention Type DRUG

one-time intranasal administration, 20 International Units, 5 puffs in each nostril

oxytocin

oxytocin condition (syntocinon)

Group Type EXPERIMENTAL

Oxytocin

Intervention Type DRUG

one-time intranasal administration, 24 International Units, 5 puffs for each nostril

placebo

Group Type PLACEBO_COMPARATOR

placebo

Intervention Type DRUG

contains all the ingredients as in the oxytocin and vasopressin conditions, save for the active ingredient, one time intranasal administration, 5 puffs in each nostril

Interventions

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Oxytocin

one-time intranasal administration, 24 International Units, 5 puffs for each nostril

Intervention Type DRUG

Arginine Vasopressin

one-time intranasal administration, 20 International Units, 5 puffs in each nostril

Intervention Type DRUG

placebo

contains all the ingredients as in the oxytocin and vasopressin conditions, save for the active ingredient, one time intranasal administration, 5 puffs in each nostril

Intervention Type DRUG

Other Intervention Names

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syntocinon

Eligibility Criteria

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Inclusion Criteria

* healthy controls

Exclusion Criteria

* Past or present psychiatric, neurological, endocrinological or severe chronic medical illness.
* Use of medications or drugs that would interfere with study results. This includes steroids, medications for psychiatric symptoms like anxiety or depression, stimulants, and medications for high blood pressure. Participants will be asked to tell the investigators of any medications or drugs that they are taking. The investigators will consider the drug interactions with oxytocin and vasopressin prior to study, and participants will not be able to participate in the study if the drug interactions could be dangerous.
* history of drug or alcohol addiction
* Pregnancy or Nursing Status: Because of the risk to an unborn fetus or infant, women who are pregnant or nursing are excluded from this protocol. All females will have a pregnancy test performed no more than 24 hours before each drug administration and will not be able to participate if the pregnancy test is positive.
Minimum Eligible Age

18 Years

Maximum Eligible Age

35 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Hebrew University of Jerusalem

OTHER

Sponsor Role collaborator

Hadassah Medical Organization

OTHER

Sponsor Role lead

Responsible Party

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Hadassah Ein-Kerem - obstetrics and gynecology

Principal Investigators

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David Mankuta, MD

Role: PRINCIPAL_INVESTIGATOR

Hadassah University Medical Organization

Locations

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Hadassah University Medical Organization

Jerusalem, Jerusalem, Israel

Site Status RECRUITING

Countries

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Israel

Central Contacts

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David Mankuta, MD

Role: CONTACT

972-2-6776484

Salomon Israel, MA

Role: CONTACT

972-524789754

Facility Contacts

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David Mankuta, MD

Role: primary

972-2-6776484

Salomon Israel, MA

Role: backup

972-52-4789754

Other Identifiers

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OXTandAVP-HMO-CTIL

Identifier Type: -

Identifier Source: org_study_id

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