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Oxytocin and Social Cognition

NCT ID: NCT01606462

Last Updated: 2014-12-03

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE1

Total Enrollment

153 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-06-30

Study Completion Date

2013-06-30

Brief Summary

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The purpose of this study is to determine whether oxytocin influences memory of social stimuli and reaction to social stimuli. Furthermore the investigators explore the effect of oxytocin receptor (OXTR) polymorphism in terms of behavioral and neural responses to social stimuli.

Detailed Description

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The prevailing view of OXT as a key facilitator of prosocial behaviors has been highly influenced by a plethora of studies in healthy volunteers, which demonstrated increased interpersonal trust, generosity, social learning/empathy and positively biased social stimulus processing as a result of OXT treatment. However, this interpretation is challenged by observations that OXT also promotes envy and schadenfreude (gloating), ethno-centrism (including prejudice, xenophobia, and racial bias), and defensive aggression towards outsiders.We investigate the neural correlates of emotion perception and subsequent memory effects of aversive and neutral stimuli. Tthe oxytocin effect on personal space is questioned. Additionally the effect of OXTR polymorphism regarding behavioral and neural response is explored.

Conditions

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Healthy Male Volunteers

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

TRIPLE

Participants Investigators Outcome Assessors

Study Groups

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Oxytocin

one application of 24 IU oxytocin per volunteer

Group Type EXPERIMENTAL

Oxytocin

Intervention Type DRUG

intranasal administration, 24 IU oxytocin; ; 3 puffs per nostril, each with 4 IU OXT

Placebo

sodium chloride solution, intranasal application, 3 puffs per nostril one application per volunteer

Group Type PLACEBO_COMPARATOR

Oxytocin

Intervention Type DRUG

intranasal administration, 24 IU oxytocin; ; 3 puffs per nostril, each with 4 IU OXT

Interventions

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Oxytocin

intranasal administration, 24 IU oxytocin; ; 3 puffs per nostril, each with 4 IU OXT

Intervention Type DRUG

Other Intervention Names

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Oxytocin: Syntocinon-Spray, Novartis

Eligibility Criteria

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Inclusion Criteria

* Healthy male volunteers

Exclusion Criteria

* Current or past psychiatric disease
* Current or past physical illness
* Psychoactive medication
* Tobacco smokers
* MRI contraindication
Minimum Eligible Age

20 Years

Maximum Eligible Age

35 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes

Sponsors

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University Hospital, Bonn

OTHER

Sponsor Role lead

Responsible Party

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Rene Hurlemann

MSc MD PhD

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Rene Hurlemann, MSc MD PhD

Role: PRINCIPAL_INVESTIGATOR

Department of Psychiatry, University of Bonn, Germany

Locations

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Department of Psychiatry, University of Bonn

Bonn, , Germany

Site Status

Countries

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Germany

Related Links

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http://renehurlemann.squarespace.com/welcome/

Click here for more information about the NEMO research group

Other Identifiers

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OXT-071/10

Identifier Type: -

Identifier Source: org_study_id