Role of Oxytocin in Telling and Detecting Lies

NCT ID: NCT02361177

Last Updated: 2016-06-13

Basic Information

• Recruitment Status: WITHDRAWN
• Clinical Phase: EARLY_PHASE1
• Study Classification: INTERVENTIONAL
• Study Start Date: 2016-01-31
• Study Completion Date: 2016-04-30

Brief Summary

The investigators are interested in the impact of intranasal oxytocin in unethical behavior.

Detailed Description

The objective of this project is to further explore the role of oxytocin in moral judgment and ethical behavior. Oxytocin is a peptide hormone produced in a variety of hypothalamic neurons. It is released into the brain or brought into general circulation through sensory stimuli in a pulsatile fashion. In social psychology research, oxytocin is hypothesized to coordinate both the causes and effects of positive social interactions in a biofeedback loop.

Conditions

Dyssocial Behavior

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: BASIC_SCIENCE
• Blinding Strategy: TRIPLE

Study Groups

oxytocin

Intranasal 24 IU oxytocin self-administration.

Group Type: EXPERIMENTAL

Oxytocin

Intervention Type: DRUG

Intranasal oxytocin is hypothesized to amplify the influence of social norms on unethical behavior.

placebo

Intranasal placebo. 125 mg of 0.5% cholorobutanol to 50 ml saline, with approximately 5 pH. The solution will then be sterilized using a 0.22 micron filter.

Group Type: PLACEBO_COMPARATOR

Oxytocin

Intervention Type: DRUG

Intranasal oxytocin is hypothesized to amplify the influence of social norms on unethical behavior.

Interventions

Oxytocin

Intranasal oxytocin is hypothesized to amplify the influence of social norms on unethical behavior.

Intervention Type: DRUG

Other Intervention Names

syntocinon

Eligibility Criteria

Inclusion Criteria

• Male

Exclusion Criteria

• _____ _____BP > 130/85, HRT > 95 (can be included at discretion of study physician/designee)

• _____History of seizures
• _____Neurological Disorder
• _____Current psychiatric disorder
• _____Previous psychiatric disorder (can be included at discretion of PI)
• Date last episode (if > 1 year, include; if <1 year, at discretion of PI)
• _____Current use of psychoactive drugs
• _____Previous use of psychoactive drugs (can be included at discretion of PI) _____Date last medicated_____ _____Type of medication___________________________________
• _____Current use of anticoagulants
• _____Current use of corticosteroids
• _____Previous head trauma (can be included at discretion of PI)
• _____Alcoholism or substance abuse
• _____Carcinoma of the breast or prostate
• _____Renal or Hepatic diseases
• _____Chronic lung diseases
• _____Cancer
• _____Liver problems
• _____Hypertension/Cardiac diseases
• _____Cardiovascular Disease
• _____Nephritis
• _____Diabetes (use of insulin) /Obesity
• _____Endocrine disease or malignancy
• _____Asthma (can be included as discretion of study physician/designee, if episodes are infrequent, nonmedicated, and no active problems at time of study)
• Medication
• Frequency of episodes____ _____Date of last episode_____
• _____Migraines(can be included as discretion of study physician/designee, if episodes are infrequent, nonmedicated, and no active problems at time of study)
• Medication _____Frequency of migraines_____ _____Date of last migraine_____
• _____High levels of physical contact with women or children

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 30 Years
• Eligible Sex: MALE
• Accepts Healthy Volunteers: Yes

Sponsors

Harvard University

OTHER

Sponsor Role: collaborator

University of Texas at Austin

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Robert A Josephs, PhD

Role: PRINCIPAL_INVESTIGATOR

utaustin

References

Kosfeld M, Heinrichs M, Zak PJ, Fischbacher U, Fehr E. Oxytocin increases trust in humans. Nature. 2005 Jun 2;435(7042):673-6. doi: 10.1038/nature03701.

Reference Type: RESULT

PMID: 15931222 (View on PubMed)

Other Identifiers

2013-11-0033

Identifier Type: -

Identifier Source: org_study_id